The current research proposal aims to implement new stimuli in an investigation of the underlying neural substrates involved in auditory local and global perceptual organization. To accomplish this goal, we plan to test patients with unilateral lesions to the posterior superior temporal gyrus and the surrounding temporal-parietal association cortex, with special attention to whether lateralization of function occurs as in visual hierarchical processing (namely, biases for right and left hemisphere involvement in global and local processing, respectively). These investigations will be complemented with a follow up experiment investigating whether, in neurologically-intact individuals, rTMS over right or left pSTG/TPJ can produce selective deficits in global or local auditory processing, respectively. Combining neuropsychology and TMS provides the opportunity to distinguish between deficits due to neural reorganization after stroke or simply to focal disruption. Together, the proposed studies will provide the candidate with a wealth of novel training opportunities. The current research will also result in a valuable collection of data from convergent approaches to examining brain-behavior relationships necessary for auditory perceptual organization. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32NS055531-02
Application #
7364589
Study Section
Special Emphasis Panel (ZRG1-F12A-H (20))
Program Officer
Babcock, Debra J
Project Start
2007-02-12
Project End
2009-02-11
Budget Start
2008-02-12
Budget End
2009-02-11
Support Year
2
Fiscal Year
2008
Total Cost
$43,276
Indirect Cost
Name
University of Wales, Bangor
Department
Type
DUNS #
497267062
City
Bangor
State
Country
United Kingdom
Zip Code
LL57 -2DG
List, Alexandra; Landau, Ayelet N; Brooks, Joseph L et al. (2011) Shifting attention in viewer- and object-based reference frames after unilateral brain injury. Neuropsychologia 49:2090-6
List, Alexandra; Justus, Timothy (2010) Relative priming of temporal local--global levels in auditory hierarchical stimuli. Atten Percept Psychophys 72:193-208
Bultitude, Janet H; Rafal, Robert D; List, Alexandra (2009) Prism adaptation reverses the local processing bias in patients with right temporo-parietal junction lesions. Brain 132:1669-77