The proposed research will explore the use of spectral and coherence information in biomedical optical imaging for identifying biological tissue properties. Two novel optical systems are proposed for collecting spectral and coherence information about light scattered from biological samples. The optical systems will be used to examine the light scattered from suspensions of cells, suspensions of cell organelles, and cell monolayers to discern what medically relevant information can be obtained. The proposed studies will serve as a basis for developing models of light scattering by biological tissues.
| Wax, Adam; Yang, Changhuei; Muller, Markus G et al. (2003) In situ detection of neoplastic transformation and chemopreventive effects in rat esophagus epithelium using angle-resolved low-coherence interferometry. Cancer Res 63:3556-9 |
| Wax, Adam; Yang, Changhuei; Backman, Vadim et al. (2002) Cellular organization and substructure measured using angle-resolved low-coherence interferometry. Biophys J 82:2256-64 |
| Wax, Adam; Yang, Changhuei; Backman, Vadim et al. (2002) Determination of particle size by using the angular distribution of backscattered light as measured with low-coherence interferometry. J Opt Soc Am A Opt Image Sci Vis 19:737-44 |
