It is the aim of my research to investigate the effects of short- and long-term maternal ethanol consumption on the immune system of infants, specifically studying its effects on the intrahepatic proliferation and differentiation of hematopoietic progenitors. I hypothesize that ethanol consumption affects the proliferation and differentiation of these cells, thus decreasing the ability of the progenitor cells to seed the immune system. Various entities will be investigated such as: (1) distinct microenvironmentaI elements (mitogens and cytokines); (2) apoptosis and proliferation; (3) absolute and relative counts of lymphocytic progenitors, macrophages, and other non-lymphoid cells in the liver; and (4) phenotypic profiles using Mabs to lineage-specific surface markers.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
MARC (NRSA) Faculty Fellowships (F34)
Project #
5F34GM018538-02
Application #
2518853
Study Section
Minority Programs Review Committee (MPRC)
Project Start
1997-08-15
Project End
Budget Start
1997-08-15
Budget End
1998-08-14
Support Year
2
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Louisiana State University Hsc Shreveport
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
City
Shreveport
State
LA
Country
United States
Zip Code
71103
Robinson, Regina S; Seelig Jr, Leonard L (2002) Effects of maternal ethanol consumption on hematopoietic cells in the rat fetal liver. Alcohol 28:151-6