Abstract

The application requests funds to continue the development and enhancement of the MBL and the TCL, to increase the level of support services to the investigators, and to conform with the technological advances made in biotechnology. These facilities will have the capability to: 1) isolate and maintain different cell types from specific tissue in in vitro cell culture systems; 2) isolate and characterize biomolecules such as proteins, enzymes, and nucleic acids; 3) generate monoclonal and polyclonal antibodies; 4) produce recombinant proteins for various uses; 5) isolate genes of interest and their potential use in gene therapy; and 6) perform in vitro assays for cytotoxicity and bioactivity of cellular and non-cellular compounds. The major general goals of the MBL and TCL facilities are to: 1) provide research infrastructure to facilitate research training of both faculty and graduate students; 2) create a research environment that leads to information exchange and technology; 3) enhance the research capabilities and competitiveness of research investigators to obtain extramural funding; and 4) institutionalize the MBL and TCL core facilities.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Research Centers in Minority Institutions Award (G12)
Project #
5G12RR003045-15
Application #
6651808
Study Section
Project Start
2002-09-01
Project End
2003-08-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
15
Fiscal Year
2002
Total Cost
$134,676
Indirect Cost

  Publications

Oloyo, Ahmed K; Sofola, Olusoga A; Yakubu, Momoh A (2016) Orchidectomy attenuates high-salt diet-induced increases in blood pressure, renovascular resistance, and hind limb vascular dysfunction: role of testosterone. Clin Exp Pharmacol Physiol 43:825-33
Oyagbemi, Ademola Adetokunbo; Omobowale, Temidayo Olutayo; Adedapo, Adeolu Alex et al. (2016) Kolaviron, Biflavonoid Complex from the Seed of Garcinia kola Attenuated Angiotensin II- and Lypopolysaccharide-induced Vascular Smooth Muscle Cell Proliferation and Nitric Oxide Production. Pharmacognosy Res 8:S50-5
Liang, Su; Bian, Xiaomei; Liang, Dong et al. (2016) Solution formulation development and efficacy of MJC13 in a preclinical model of castration-resistant prostate cancer. Pharm Dev Technol 21:121-6
Robinson, Keila; Mock, Charlotta; Liang, Dong (2015) Pre-formulation studies of resveratrol. Drug Dev Ind Pharm 41:1464-9
Wang, Yan; Ye, Yuanqing; Lin, Jie et al. (2015) Genetic variants in matrix metalloproteinase genes as disposition factors for ovarian cancer risk, survival, and clinical outcome. Mol Carcinog 54:430-9
Liang, Su; Sanchez-Espiridion, Beatriz; Xie, Huan et al. (2015) Determination of proline in human serum by a robust LC-MS/MS method: application to identification of human metabolites as candidate biomarkers for esophageal cancer early detection and risk stratification. Biomed Chromatogr 29:570-7
Jimenez, Angelica; Adisa, Afolabi; Woodham, Cara et al. (2014) Determination of polycyclic aromatic hydrocarbons in roasted coffee. J Environ Sci Health B 49:828-35
Bell, Edward C; John, Mathew; Hughes, Rodney J et al. (2014) Ultra-performance liquid chromatographic determination of tocopherols and retinol in human plasma. J Chromatogr Sci 52:1065-70
Meng, Qing H; Xu, Enping; Hildebrandt, Michelle A T et al. (2014) Genetic variants in the fibroblast growth factor pathway as potential markers of ovarian cancer risk, therapeutic response, and clinical outcome. Clin Chem 60:222-32
Liang, Su; Bian, Xiaomei; Sivils, Jeffrey et al. (2014) Quantification of a New Anti-Cancer Molecule MJC13 Using a Rapid, Sensitive, and Reliable Liquid Chromatography-Tandem Mass Spectrometry Method. Am J Mod Chromatogr 1:1-11

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