Abstract

The overall and overarching goal of the proposed studies is the development of fundamental understanding necessary for preparing peptide/biocompatible polymer macromolecular complexes as 21st-century biofunctional materials. In order to accomplish this goal, a detailed understanding of the forces necessary for the formation of stable model peptide/biocompatible polymer complexes will be developed. The forces contributing to the formation of stable complexes are a combination of ion-dipole, hydrophobic and H-bonding interactions, and will be elucidated by using 2-D NOESY NMR spectroscopy, circular dichroism (CD) spectroscopy and light scattering studies in a complementary fashion. Additionally, the current understanding of the formation of stable model peptide/poly(ethylene oxide)(PEO) complexes will be applied to the development of stable PEO/arginine-glycine-aspartic acid (RGD) complex as a bioadhesive extracellular material. The preliminary bioadhesive properties of the PEO/RGD macromolecular complexes will be determined by studying adherence of cells to thin films of the complexes. The adhesive interaction of synthetic extracellular material will find application in controlled and targeted drug delivery to specific organ or cell via a """"""""key and lock"""""""" mechanism.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Research Centers in Minority Institutions Award (G12)
Project #
3G12RR003062-16S1
Application #
6661595
Study Section
Project Start
2002-09-19
Project End
2003-06-30
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
16
Fiscal Year
2002
Total Cost
$88,647
Indirect Cost

  Institution

Name
Clark Atlanta University
Department
Type
DUNS #
065325177
City
Atlanta
State
GA
Country
United States
Zip Code
30314

  Publications

Morton, Derrick J; Patel, Divya; Joshi, Jugal et al. (2017) ID4 regulates transcriptional activity of wild type and mutant p53 via K373 acetylation. Oncotarget 8:2536-2549
Joshi, Jugal Bharat; Patel, Divya; Morton, Derrick J et al. (2017) Inactivation of ID4 promotes a CRPC phenotype with constitutive AR activation through FKBP52. Mol Oncol 11:337-357
Komaragiri, Shravan Kumar; Bostanthirige, Dhanushka H; Morton, Derrick J et al. (2016) ID4 promotes AR expression and blocks tumorigenicity of PC3 prostate cancer cells. Biochem Biophys Res Commun 478:60-66
Wilder, Catera L; Walton, Charlene; Watson, Valencia et al. (2016) Differential cathepsin responses to inhibitor-induced feedback: E-64 and cystatin C elevate active cathepsin S and suppress active cathepsin L in breast cancer cells. Int J Biochem Cell Biol 79:199-208
Brown, Shanora G; Knowell, Ashley E; Hunt, Aisha et al. (2015) Interferon inducible antiviral MxA is inversely associated with prostate cancer and regulates cell cycle, invasion and Docetaxel induced apoptosis. Prostate 75:266-79
Muniyan, Sakthivel; Chou, Yu-Wei; Tsai, Te-Jung et al. (2015) p66Shc longevity protein regulates the proliferation of human ovarian cancer cells. Mol Carcinog 54:618-31
Chinaranagari, Swathi; Sharma, Pankaj; Bowen, Nathan J et al. (2015) Prostate cancer epigenome. Methods Mol Biol 1238:125-40
Burton, Liza J; Smith, Basil A; Smith, Bethany N et al. (2015) Muscadine grape skin extract can antagonize Snail-cathepsin L-mediated invasion, migration and osteoclastogenesis in prostate and breast cancer cells. Carcinogenesis 36:1019-27
Goodson 3rd, William H; Lowe, Leroy; Carpenter, David O et al. (2015) Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead. Carcinogenesis 36 Suppl 1:S254-96
Mandal, S; Abebe, F; Chaudhary, J (2014) -174G/C polymorphism in the interleukin-6 promoter is differently associated with prostate cancer incidence depending on race. Genet Mol Res 13:139-51

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