This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The Major Instrumentation Core will be established as one of the three core laboratories for the RCMI program. It will provide technical services and consumable supplies necessary for the operation and maintenance of a variety of major instruments that support biomedical research at Xavier University. In addition to designating/centralizing several existing analytical instruments for use and service by the Core, funds are requested to purchase two new instruments: an HPLC-MS/MS and a 300 MHz NMR system over the project period. The long term goal of the Major Instrumentation Core is to enhance the overall biomedical research capabilities at Xavier University by making available essential instrument-based platforms for various research projects. To achieve this goal the Major Instrumentation Core has set the following specific aims: 1. support biomedical research projects on campus by providing essential analytical instrumentation, 2. maintain and operate existing instruments, 3. acquire new instruments, and 4. provide technical support for user community of the core. The Major Instrumentation Core will be managed by a faculty manager, Jian Zhang P.h.D., and an assistant faculty manager, Qiang Zhang, and will staff a full time analytical chemist with extensive experiences in operating and maintaining major analytical instruments. Operation of the Core will follow guidelines specified in the Standard Operation Procedures (SOP) that will be revised as the Core expands and evolves.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
Research Centers in Minority Institutions Award (G12)
Project #
Application #
Study Section
Special Emphasis Panel (ZRR1-RI-B (01))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Xavier University of Louisiana
Other Domestic Higher Education
New Orleans
United States
Zip Code
Graves, Richard A; Ledet, Grace; Nation, Cedric A et al. (2015) An ultra-high performance chromatographic method for the determination of artemisinin. Drug Dev Ind Pharm 41:819-24
Bratton, Melyssa R; Martin, Elizabeth C; Elliott, Steven et al. (2015) Glyceollin, a novel regulator of mTOR/p70S6 in estrogen receptor positive breast cancer. J Steroid Biochem Mol Biol 150:17-23
Dougherty, Casey A; Furgal, Joseph C; van Dongen, Mallory A et al. (2014) Isolation and characterization of precise dye/dendrimer ratios. Chemistry 20:4638-45
Nilov, Denis; Kucheryavy, Pavel; Walker, Verina et al. (2014) Synthesis of 5-Substituted Derivatives of Isophthalic Acid as Non-Polymeric Amphiphilic Coating for Metal Oxide Nanoparticles. Tetrahedron Lett 55:5078-5081
Strong, Amy L; Ohlstein, Jason F; Jiang, Quan et al. (2014) Novel daidzein analogs enhance osteogenic activity of bone marrow-derived mesenchymal stem cells and adipose-derived stromal/stem cells through estrogen receptor dependent and independent mechanisms. Stem Cell Res Ther 5:105
Ponnapakam, Adharsh P; Liu, Jiawang; Bhinge, Kaustubh N et al. (2014) 3-Ketone-4,6-diene ceramide analogs exclusively induce apoptosis in chemo-resistant cancer cells. Bioorg Med Chem 22:1412-20
McFerrin, Harris E; Olson, Scott D; Gutschow, Miriam V et al. (2014) Rapidly self-renewing human multipotent marrow stromal cells (hMSC) express sialyl Lewis X and actively adhere to arterial endothelium in a chick embryo model system. PLoS One 9:e105411
Ledet, Grace; Pamujula, Sarala; Walker, Valencia et al. (2014) Development and in vitro evaluation of a nanoemulsion for transcutaneous delivery. Drug Dev Ind Pharm 40:370-9
Tilghman, Syreeta L; Rhodes, Lyndsay V; Bratton, Melyssa R et al. (2013) Phytoalexins, miRNAs and breast cancer: a review of phytochemical-mediated miRNA regulation in breast cancer. J Health Care Poor Underserved 24:36-46
Jiang, Quan; Zheng, Shilong; Wang, Guangdi (2013) Development of new estrogen receptor-targeting therapeutic agents for tamoxifen-resistant breast cancer. Future Med Chem 5:1023-35

Showing the most recent 10 out of 63 publications