The present studies are aimed at further understanding the neurophysiology of ethanol consumption. In prior studies, with Dr. Herman Samson and Dr. Cindy Ehlers, the applicant has begun to examine the behavioral regulation of ethanol intake and the neurophysiological mechanisms associated with ethanol exposure. The present Mentored Research Scientist Development Award will allow for the continued training in the neurophysiological recording techniques and animal models of ethanol consumption necessary to merge the applicants two primary interests: ethanol drinking and brain macrophysiology. The award will allow for the development of the applicant's scientific expertise through 1) the training and supervision of a qualified mentor, 2) career development activities with distinguished researchers in various fields of alcohol research, and 3) the completion of studies designed to assess the neurophysiological mechanisms regulating ethanol consumption. These studies combine an alcohol consumption model (Standard Limited Access Drinking and Limited Access Drinking after Alcohol Deprivation) with state-of-the art electrophysiological techniques (EEG and ERPS) to further understand the neural determinants of alcohol consumption in an animal model. The proposed studies utilize manipulations of ethanol consumption that target behavioral and environmental factors important in regulating ethanol intake such as conditioned stimuli, """"""""relapse"""""""", and """"""""craving"""""""". The different manipulations generate moderate to transiently excessive ethanol intake allowing for the assessment of concurrent changes in the functional electrical activity of multiple brain regions during initiation, maintenance and """"""""relapse"""""""" stages of drinking behavior. In addition, ethanol intake will be manipulated by examining the effects of ethanol exposure during development (neonatal and periadolescent exposure) to assess its relation to ethanol consumption and neurophysiological activity. These studies are among the first to systematically assess the macro-neurophysiological activity in the mesocorticolimbic circuit involved ethanol intake and its relation to various ethanol consumption paradigms.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Scientist Development Award - Research & Training (K01)
Project #
5K01AA000298-02
Application #
6371247
Study Section
Health Services Research Review Subcommittee (AA)
Program Officer
Egli, Mark
Project Start
2000-07-01
Project End
2005-06-30
Budget Start
2001-07-01
Budget End
2002-06-30
Support Year
2
Fiscal Year
2001
Total Cost
$90,574
Indirect Cost
Name
Scripps Research Institute
Department
Type
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Slawecki, Craig J; Roth, Jennifer; Gilder, Allison (2006) Neurobehavioral profiles during the acute phase of ethanol withdrawal in adolescent and adult Sprague-Dawley rats. Behav Brain Res 170:41-51
Slawecki, Craig J (2006) Two-choice reaction time performance in Sprague-Dawley rats exposed to alcohol during adolescence or adulthood. Behav Pharmacol 17:605-14
Slawecki, Craig J; Ehlers, Cindy L (2005) Enhanced prepulse inhibition following adolescent ethanol exposure in Sprague-Dawley rats. Alcohol Clin Exp Res 29:1829-36
Slawecki, Craig J (2005) Comparison of anxiety-like behavior in adolescent and adult Sprague-Dawley rats. Behav Neurosci 119:1477-83
Slawecki, Craig J; Roth, Jennifer (2004) Comparison of the onset of hypoactivity and anxiety-like behavior during alcohol withdrawal in adolescent and adult rats. Alcohol Clin Exp Res 28:598-607
Slawecki, Craig J; Thomas, Jennifer D; Riley, Edward P et al. (2004) Neurophysiologic consequences of neonatal ethanol exposure in the rat. Alcohol 34:187-96
Slawecki, Craig J; Roth, Jennifer (2003) Neurokinin type-3 receptor stimulation impairs ethanol-associated appetitive behavior in Wistar rats. Alcohol Clin Exp Res 27:1962-70
Slawecki, Craig J (2002) Altered EEG responses to ethanol in adult rats exposed to ethanol during adolescence. Alcohol Clin Exp Res 26:246-54
Slawecki, Craig J; Betancourt, Michelle (2002) Effects of adolescent ethanol exposure on ethanol consumption in adult rats. Alcohol 26:23-30
Katner, S N; Slawecki, C J; Ehlers, C L (2002) Neurophysiological profiles of replicate line 2 high-alcohol-drinking (HAD-2) and low-alcohol-drinking (LAD-2) rats. Alcohol Clin Exp Res 26:1669-77

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