This Mentored Research Scientist Development Award will support the candidate in establishing an independent research career as a methodologist who develops cutting-edge statistical methodology with direct applications in alcoholism and substance abuse prevention. Career development training areas include: 1) Development psychopathology;2) Alcoholism and substance abuse prevention research and methodology;3) Modern computational techniques;and 4) Modeling longitudinal data using nonparametric regression.
The specific aims of the proposed research plan are: 1) To develop a new Bayesian latent variable model for assessing dynamic childhood risk for alcoholism in multiple dimensions;2) To develop a new semi-parametric regression model for validating the association between childhood risk and adolescent substance use development;and 3) To apply the methodologies developed in Specific Aims 1 and 2 to test hypotheses based on the data collected from an ongoing 21-year long prospective study of families at high risk for alcoholism. The methodology developed in this study will be useful in establishing construct validity of commonly used measures of childhood risk. Two statistical programs will be developed and distributed to prevention scientists. The derived longitudinal model based on the empirical data should be useful in projecting a new child's developmental trajectory of adolescent substance use based on his/her childhood risk measures. Thus, it has the potential to provide crucial information about the timing and dose an individual child needs for early intervention.

Public Health Relevance

Alcohol use, alcohol problems and alcohol symptomatology are all developmental phenomena. The applicant's work would develop new methodology which allows for more accurate description of these developmental relationships than is allowed by currently available methods and takes account of the special statistical properties of the measures most commonly used by the field.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Scientist Development Award - Research & Training (K01)
Project #
5K01AA016591-04
Application #
8249520
Study Section
Health Services Research Review Subcommittee (AA)
Program Officer
Zha, Wenxing
Project Start
2009-04-10
Project End
2014-03-31
Budget Start
2012-04-01
Budget End
2013-03-31
Support Year
4
Fiscal Year
2012
Total Cost
$155,161
Indirect Cost
$11,493
Name
University of Michigan Ann Arbor
Department
Psychiatry
Type
Schools of Medicine
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
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