Caloric restriction has been shown in numerous studies in rodents to extend the maximal life span, retard age-associated physiological changes and delay or prevent most age associated disease. If these findings are to be extrapolated to human beings, it will first be necessary to test varying dietary regimens in some higher species and evaluate the effect on an age-related disease process, particularly as it relates to human health. As such, age related disease such as atherosclerosis would be a valuable end point to study. To diminish atherosclerosis, the caloric restriction should alter pathogenic mechanisms contributing to the disease process. Therefore, the proposed research will evaluate a well characterized non -human primate model for human atherosclerosis and study dietary intervention in the form of caloric restriction compared to unrestricted diet with equivalent cholesterol content. We will evaluate for changes secondary to the dietary restriction on insulin resistance, arterial collagen glycation/advanced glycation, and adipose distribution, all of which have been strongly implicated in contributing to cardiovascular disease. The changes in our parameters secondary to dietary intervention, will be related to changes in atherosclerosis assessed at study completion.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Scientist Development Award - Research & Training (K01)
Project #
5K01AG000578-04
Application #
2048356
Study Section
Biological and Clinical Aging Review Committee (BCA)
Project Start
1992-09-30
Project End
1997-08-31
Budget Start
1995-09-01
Budget End
1996-08-31
Support Year
4
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Wake Forest University Health Sciences
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
041418799
City
Winston-Salem
State
NC
Country
United States
Zip Code
27106
Cefalu, W T; Terry, J G; Thomas, M J et al. (2000) In vitro oxidation of low-density lipoprotein in two species of nonhuman primates subjected to caloric restriction. J Gerontol A Biol Sci Med Sci 55:B355-61
Cefalu, W T; Wagner, J D; Wang, Z Q et al. (1997) A study of caloric restriction and cardiovascular aging in cynomolgus monkeys (Macaca fascicularis): a potential model for aging research. J Gerontol A Biol Sci Med Sci 52:B10-9
Wagner, J D; Bagdade, J D; Litwak, K N et al. (1996) Increased glycation of plasma lipoproteins in diabetic cynomolgus monkeys. Lab Anim Sci 46:31-5