Aging, Diabetes and Vascular Disease

Schmidt, Ann Marie

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute on Aging (NIA)
• Type: Research Scientist Development Award - Research & Training (K01)
• Project #: 5K01AG000602-04
• Application #: 2048407
• Study Section: Biological and Clinical Aging Review Committee (BCA)
• Program Officer: Finkelstein, David B
• Project Start: 1993-07-01
• Project End: 1998-06-30
• Budget Start: 1996-07-01
• Budget End: 1997-06-30
• Support Year: 4
• Fiscal Year: 1996

Institution

• Name: Columbia University (N.Y.)
• Department: Internal Medicine/Medicine
• Type: Schools of Medicine
• DUNS #: 167204994
• City: New York
• State: NY
• Country: United States
• Zip Code: 10032

Publications

Schmidt, A M; Hori, O; Chen, J X et al. (1995) Advanced glycation endproducts interacting with their endothelial receptor induce expression of vascular cell adhesion molecule-1 (VCAM-1) in cultured human endothelial cells and in mice. A potential mechanism for the accelerated vasculopathy of diabetes. J Clin Invest 96:1395-403

Yan, S D; Schmidt, A M; Anderson, G M et al. (1994) Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors/binding proteins. J Biol Chem 269:9889-97

Schmidt, A M; Mora, R; Cao, R et al. (1994) The endothelial cell binding site for advanced glycation end products consists of a complex: an integral membrane protein and a lactoferrin-like polypeptide. J Biol Chem 269:9882-8

Wautier, J L; Wautier, M P; Schmidt, A M et al. (1994) Advanced glycation end products (AGEs) on the surface of diabetic erythrocytes bind to the vessel wall via a specific receptor inducing oxidant stress in the vasculature: a link between surface-associated AGEs and diabetic complications. Proc Natl Acad Sci U S A 91:7742-6

Schmidt, A M; Hori, O; Brett, J et al. (1994) Cellular receptors for advanced glycation end products. Implications for induction of oxidant stress and cellular dysfunction in the pathogenesis of vascular lesions. Arterioscler Thromb 14:1521-8