Abstract

The effects of age and exercise intensity of physical conditioning on claudication pain symptoms and leg circulation of patients with intermittent claudication will be examined. It is hypothesized that (1) older patients (greater than 70 years of age) will have greater disease severity, and greater relative improvements in claudication pain and leg circulation following 4 months of exercise rehabilitation than younger patients (greater than 60 years of age), and (2) the improvements of both age groups will be greater following a rehabilitation program that uses higher exercise intensity (70% of walking capacity) that a program that uses lower intensity (40% of walking capacity)> The clinical significance of these anticipated findings is the exercise rehabilitation becomes more effective in the treatment of claudication pain as patients age, and a program should consist of exercise at higher rather than lower intensity for greater improvements in claudication pain and leg circulation, which may circumvent disease progression to more serious endpoints.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Scientist Development Award - Research & Training (K01)
Project #
5K01AG000657-02
Application #
2048501
Study Section
Biological and Clinical Aging Review Committee (BCA)
Project Start
1994-03-15
Project End
1998-11-30
Budget Start
1995-02-01
Budget End
1996-01-31
Support Year
2
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
University of Maryland Baltimore
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
003255213
City
Baltimore
State
MD
Country
United States
Zip Code
21201

  Publications

Gardner, Andrew W; Montgomery, Polly S; Parker, Donald E (2012) Optimal exercise program length for patients with claudication. J Vasc Surg 55:1346-54
Gardner, Andrew W; Montgomery, Polly S; Ritti-Dias, Raphael M et al. (2010) The effect of claudication pain on temporal and spatial gait measures during self-paced ambulation. Vasc Med 15:21-6
Gardner, Andrew W; Montgomery, Polly S (2010) Resting energy expenditure in patients with intermittent claudication and critical limb ischemia. J Vasc Surg 51:1436-41
Gardner, Andrew W; Montgomery, Polly S (2009) Resting energy expenditure in subjects with and without intermittent claudication. Metabolism 58:1008-12
Gardner, Andrew W; Montgomery, Polly S; Parker, Donald E (2008) Physical activity is a predictor of all-cause mortality in patients with intermittent claudication. J Vasc Surg 47:117-22
Gardner, Andrew W; Montgomery, Polly S (2008) The effect of metabolic syndrome components on exercise performance in patients with intermittent claudication. J Vasc Surg 47:1251-8
Gardner, Andrew W; Montgomery, Polly S; Afaq, Azhar (2007) Exercise performance in patients with peripheral arterial disease who have different types of exertional leg pain. J Vasc Surg 46:79-86
Killewich, Lois A; Macko, Richard F; Montgomery, Polly S et al. (2004) Exercise training enhances endogenous fibrinolysis in peripheral arterial disease. J Vasc Surg 40:741-5
Atkins, LeighAnn M; Gardner, Andrew W (2004) The relationship between lower extremity functional strength and severity of peripheral arterial disease. Angiology 55:347-55
Waldstein, Shari R; Tankard, Carol F; Maier, Karl J et al. (2003) Peripheral arterial disease and cognitive function. Psychosom Med 65:757-63

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