Candidate - The candidate, Christopher Bell, Ph.D., is a physiologist currently supported by an individual postdoctoral fellowship from the American Heart Association. Dr. Bell's past and current research focus has been on the effect of physiological aging on resting and exercise energy expenditure. His immediate goal is to acquire new research and professional skills to help him achieve his long-term goal of developing a successful independent extramurally-funded research program in aging. The proposed K01 development plan should provide Dr. Bell with the necessary training to achieve his goal. Career Development Plan - Dr. Bell's proposed research career development activities consist of: 1) acquiring new research skills associated with and complementary to the proposed research plan; and 2) structured activities including formal course work; attendance and presentation at journal clubs, seminar series, and scientific meetings; and regular interactions with his mentoring team. The overall plan is based on a """"""""translational research"""""""" training model. Environment - The environment for Dr. Bell's research training should be outstanding. The sponsor, Dr. Douglas Seals, is a well-established extramurally-funded scientist with a strong record of successful mentoring in biomedical aging research. He is complemented by several consulting mentors who will provide guidance in specific areas of the training plan. Other faculty in aging research enhances the local training environment. Research - The general aim of this research is to increase our understanding of the mechanisms responsible for changes in beta-adrenergic receptor sympathetic nervous system (beta-AR SNS) modulation of resting metabolic rate (RMR) and thermogenesis with aging in adult humans. I will determine the influence of energy flux (the level of dietary intake and energy expenditure while in energy balance), increased beta-AR responsiveness, and beta2-AR gene variants on beta-AR SNS support of RMR and thermogenesis in middle-aged and older adult humans.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Scientist Development Award - Research & Training (K01)
Project #
5K01AG022053-05
Application #
7189922
Study Section
National Institute on Aging Initial Review Group (NIA)
Program Officer
Rossi, Winifred K
Project Start
2004-02-15
Project End
2009-01-31
Budget Start
2007-03-15
Budget End
2008-01-31
Support Year
5
Fiscal Year
2007
Total Cost
$122,494
Indirect Cost
Name
Colorado State University-Fort Collins
Department
Miscellaneous
Type
Other Domestic Higher Education
DUNS #
785979618
City
Fort Collins
State
CO
Country
United States
Zip Code
80523
Paxton, Roger J; Malcolm, Matthew P; Newsom, Sean A et al. (2011) Sympathetic responses to repetitive trans-spinal magnetic stimulation. Clin Auton Res 21:81-7
Lonac, Mark C; Richards, Jennifer C; Schweder, Melani M et al. (2011) Influence of short-term consumption of the caffeine-free, epigallocatechin-3-gallate supplement, Teavigo, on resting metabolism and the thermic effect of feeding. Obesity (Silver Spring) 19:298-304
Newsom, Sean A; Richards, Jennifer C; Johnson, Tyler K et al. (2010) Short-term sympathoadrenal inhibition augments the thermogenic response to beta-adrenergic receptor stimulation. J Endocrinol 206:307-15
Richards, Jennifer C; Lonac, Mark C; Johnson, Tyler K et al. (2010) Epigallocatechin-3-gallate increases maximal oxygen uptake in adult humans. Med Sci Sports Exerc 42:739-44
Newsom, Sean A; Paxton, Roger J; Rynn, Grant M et al. (2008) Influence of ascorbic acid on the thermic effect of feeding in overweight and obese adult humans. Obesity (Silver Spring) 16:1749-54
Stob, Nicole R; Seals, Douglas R; Jorgen, Jensen et al. (2007) Increased thermogenic responsiveness to intravenous beta-adrenergic stimulation in habitually exercising humans is not related to skeletal muscle beta2-adrenergic receptor density. Exp Physiol 92:823-30
Stob, Nicole R; Bell, Christopher; van Baak, Marleen A et al. (2007) Thermic effect of food and beta-adrenergic thermogenic responsiveness in habitually exercising and sedentary healthy adult humans. J Appl Physiol 103:616-22
Bell, Christopher; Stob, Nicole R; Seals, Douglas R (2006) Thermogenic responsiveness to nonspecific beta-adrenergic stimulation is not related to genetic variation in codon 16 of the beta2-adrenergic receptor. Am J Physiol Endocrinol Metab 290:E703-7
Bell, Christopher; Stob, Nicole R; Seals, Douglas R (2006) Thermogenic responsiveness to beta-adrenergic stimulation is augmented in exercising versus sedentary adults: role of oxidative stress. J Physiol 570:629-35
Bell, Christopher; Carson, John M; Motte, Nathaniel W et al. (2005) Ascorbic acid does not affect the age-associated reduction in maximal cardiac output and oxygen consumption in healthy adults. J Appl Physiol 98:845-9