Candidate: The candidate, Frank A. Dinenno, Ph.D., is a physiologist currently supported by an individual NRSA from NIA. Dr. Dinenno's previous and current research focus has been on sympathetic neural control of the circulation, with specific emphasis on how these control mechanisms are modulated by advancing age and regular physical activity in humans. His immediate goal is to acquire new research and professional skills to better prepare and help him achieve his long-term goal of developing a successful independent extramurally-funded research program on aging and cardiovascular function. This proposed KO1 should provide Dr. Dinenno the necessary training to achieve his goal. Career Development Plan: Dr. Dinenno's research career development training activities will consist of (1) acquiring new research skills associated with and complimentary to the proposed research plan; and (2) structured research- and professional skills-related activities. Environment: The environment for Dr. Dinenno's training will be outstanding. The Sponsor (Dr. Joyner) and consulting mentors are engaged in biomedical research and are extramurally-funded from NIH. All are established scientists with strong records of successful mentoring in biomedical research, three of the six are experts in aging research. Support from the General Clinical Research Center will enhance the training environment. Research: The following specific aims will be addressed: 1) to determine whether whole-leg alpha-adrenergic receptor responsiveness is reduced with age under resting conditions in healthy humans, and whether this is specific for cq- or c2-adrenergic receptors; (2) to determine whether the ability to blunt-adrenergic vasoconstriction during large muscle dynamic exercise is impaired in older adults and (3) whether this impairment is due to age-related reductions in nitric oxide bioavailability mediated via elevations in oxidative stress; and (4) to determine whether a program of regular aerobic exercise improves the ability of previously sedentary older adults to blunt sympathetic vasoconstriction at rest and during exercise. The expected results should yield new information regarding sympathetic neural control of the circulation at rest and during exercise in aging humans, and the intervention study should yield novel information about training-induced adaptations and peripheral circulatory control in older adults.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Scientist Development Award - Research & Training (K01)
Project #
7K01AG022337-02
Application #
6841472
Study Section
National Institute on Aging Initial Review Group (NIA)
Program Officer
Rossi, Winifred K
Project Start
2003-09-01
Project End
2008-08-31
Budget Start
2004-02-15
Budget End
2004-08-31
Support Year
2
Fiscal Year
2003
Total Cost
$74,742
Indirect Cost
Name
Colorado State University-Fort Collins
Department
Miscellaneous
Type
Other Domestic Higher Education
DUNS #
785979618
City
Fort Collins
State
CO
Country
United States
Zip Code
80523
Crecelius, Anne R; Kirby, Brett S; Dinenno, Frank A (2015) Intravascular ATP and the regulation of blood flow and oxygen delivery in humans. Exerc Sport Sci Rev 43:5-13
Kirby, Brett S; Crecelius, Anne R; Voyles, Wyatt F et al. (2011) Modulation of postjunctional ?-adrenergic vasoconstriction during exercise and exogenous ATP infusions in ageing humans. J Physiol 589:2641-53
Markwald, Rachel R; Kirby, Brett S; Crecelius, Anne R et al. (2011) Combined inhibition of nitric oxide and vasodilating prostaglandins abolishes forearm vasodilatation to systemic hypoxia in healthy humans. J Physiol 589:1979-90
Crecelius, Anne R; Kirby, Brett S; Voyles, Wyatt F et al. (2010) Nitric oxide, but not vasodilating prostaglandins, contributes to the improvement of exercise hyperemia via ascorbic acid in healthy older adults. Am J Physiol Heart Circ Physiol 299:H1633-41
Kirby, Brett S; Crecelius, Anne R; Voyles, Wyatt F et al. (2010) Vasodilatory responsiveness to adenosine triphosphate in ageing humans. J Physiol 588:4017-27
Kirby, Brett S; Voyles, Wyatt F; Simpson, Carrie B et al. (2009) Endothelium-dependent vasodilatation and exercise hyperaemia in ageing humans: impact of acute ascorbic acid administration. J Physiol 587:1989-2003
Kirby, Brett S; Voyles, Wyatt F; Carlson, Rick E et al. (2008) Graded sympatholytic effect of exogenous ATP on postjunctional alpha-adrenergic vasoconstriction in the human forearm: implications for vascular control in contracting muscle. J Physiol 586:4305-16
Carlson, Rick E; Kirby, Brett S; Voyles, Wyatt F et al. (2008) Evidence for impaired skeletal muscle contraction-induced rapid vasodilation in aging humans. Am J Physiol Heart Circ Physiol 294:H1963-70
Kirby, Brett S; Carlson, Rick E; Markwald, Rachel R et al. (2007) Mechanical influences on skeletal muscle vascular tone in humans: insight into contraction-induced rapid vasodilatation. J Physiol 583:861-74
Smith, Erica G; Voyles, Wyatt F; Kirby, Brett S et al. (2007) Ageing and leg postjunctional alpha-adrenergic vasoconstrictor responsiveness in healthy men. J Physiol 582:63-71

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