This Career Development Award (K01) is a proposal to further my education and training in advanced biostatistics, econometrics, and health outcomes research through didactic courses and contact with a primary mentor and multidisciplinary group of experts in diverse fields ranging from infectious diseases to economics and health behavior research. The goal of this advanced training is to acquire the knowledge and skills necessary to comprehensively study the epidemiology and outcomes of surgical site infections (SSI) after breast cancer surgery, that may impact as many as 18,000 women each year in the United States. A prospective longitudinal cohort design will be used to determine accurate incidences and risk factors for SSI within 1 year after breast-conserving surgery, mastectomy, and mastectomy with immediate reconstruction. Clinical outcomes of SSI, including consequent further surgical interventions, antibiotic administration, and development of antibiotic resistance will be measured utilizing inpatient and outpatient follow-up data. The impact of SSI on overall health-related quality of life, depressive symptoms, sexual functioning, and specific issues related to the healing breast incision will be assessed multiple times after surgery. From the societal perspective, the economic costs attributable to SSI following the different types of breast surgery will be quantified using financial data obtained from inpatient hospitalizations and outpatient clinic visits. The advanced training received in biostatistics will allow for the creation of detailed statistical models to calculate the attributable costs of SSI in both the inpatient and outpatient setting. Determining accurate incidences and identification of specific risk factors for development of SSI in this surgical population will facilitate the development of risk stratification indices and infection control interventions to prevent these infections following breast cancer surgery.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Scientist Development Award - Research & Training (K01)
Project #
5K01AI065808-04
Application #
7487428
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Korpela, Jukka K
Project Start
2005-08-01
Project End
2010-06-30
Budget Start
2008-07-01
Budget End
2010-06-30
Support Year
4
Fiscal Year
2008
Total Cost
$97,453
Indirect Cost
Name
Washington University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Lankiewicz, Julie D; Yokoe, Deborah S; Olsen, Margaret A et al. (2012) Beyond 30 days: does limiting the duration of surgical site infection follow-up limit detection? Infect Control Hosp Epidemiol 33:202-4
Kasper, Amelia M; Nyazee, Humaa A; Yokoe, Deborah S et al. (2012) A multicenter study of Clostridium difficile infection-related colectomy, 2000-2006. Infect Control Hosp Epidemiol 33:470-6
Dubberke, Erik R; Nyazee, Humaa A; Yokoe, Deborah S et al. (2012) Implementing automated surveillance for tracking Clostridium difficile infection at multiple healthcare facilities. Infect Control Hosp Epidemiol 33:305-8
Marschall, Jonas; Bhavan, Kavita P; Olsen, Margaret A et al. (2011) The impact of prebiopsy antibiotics on pathogen recovery in hematogenous vertebral osteomyelitis. Clin Infect Dis 52:867-72
Olsen, Margaret A; Butler, Anne M; Willers, Denise M et al. (2010) Attributable costs of surgical site infection and endometritis after low transverse cesarean delivery. Infect Control Hosp Epidemiol 31:276-82
Olsen, Margaret A; Butler, Anne M; Willers, Denise M et al. (2010) Comparison of costs of surgical site infection and endometritis after cesarean delivery using claims and medical record data. Infect Control Hosp Epidemiol 31:872-5
Dubberke, Erik R; Butler, Anne M; Yokoe, Deborah S et al. (2010) Multicenter study of surveillance for hospital-onset Clostridium difficile infection by the use of ICD-9-CM diagnosis codes. Infect Control Hosp Epidemiol 31:262-8
Dubberke, Erik R; Butler, Anne M; Yokoe, Deborah S et al. (2010) Multicenter study of Clostridium difficile infection rates from 2000 to 2006. Infect Control Hosp Epidemiol 31:1030-7
Olsen, Margaret A; Fraser, Victoria J (2010) Use of diagnosis codes and/or wound culture results for surveillance of surgical site infection after mastectomy and breast reconstruction. Infect Control Hosp Epidemiol 31:544-7
Butler, Anne M; Olsen, Margaret A; Merz, Liana R et al. (2010) Attributable costs of enterococcal bloodstream infections in a nonsurgical hospital cohort. Infect Control Hosp Epidemiol 31:28-35

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