application): Pain is one of the major complaints of those seeking professional healthcare. Although recent advances have been made in pharmacological and invasive approaches to relief pain, many patients suffering pain chose alternative healing modalities, such as acupuncture. This application focuses on determining the neurobiological mechanisms of acupuncture analgesia (the relief of pain) in people who suffer from fibromyalgia (FM), a chronic pain condition. All proposed work will occur at the University of Michigan. The first year of funding of this proposed K award would coincide with the final year of funding of the R01 grant, allowing an opportunity to use both the research subjects and information from the existing grant to obtain preliminary data for the remainder of the K award. During the first two years of the K award, the applicant will: 1) establish the ideal conditions for acupuncture induced analgesia, and 2) begin to elucidate the mechanisms of acupuncture induced analgesia by using both psychophysical and fMRI experiments. In the final three years of the K award, the applicant will focus on the techniques that show the most promise for elucidating neural mechanisms underlying the analgesia. Comparisons will be drawn between analgesia of patient?s clinical spontaneous pain as well as evoked pain. In addition to clinical research experience, the applicant will attend didactic lectures, seminars, and conferences designed to increase his knowledge of clinical research. Although the applicant already has training in acupuncture and a strong basic research training in neuroscience, this career development program is designed to allow the Candidate to become a successful independent clinical investigator. There is a strong institutional commitment to see the applicant succeed in this task due to a tremendous need for well-trained clinical investigators in alternative and complementary medicine.

National Institute of Health (NIH)
National Center for Complementary & Alternative Medicine (NCCAM)
Research Scientist Development Award - Research & Training (K01)
Project #
Application #
Study Section
Special Emphasis Panel (ZAT1-W (01))
Program Officer
Hopp, Craig
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Michigan Ann Arbor
Internal Medicine/Medicine
Schools of Medicine
Ann Arbor
United States
Zip Code
Schrepf, Andrew; Harper, Daniel E; Harte, Steven E et al. (2016) Endogenous opioidergic dysregulation of pain in fibromyalgia: a PET and fMRI study. Pain 157:2217-2225
Ichesco, Eric; Schmidt-Wilcke, Tobias; Bhavsar, Rupal et al. (2014) Altered resting state connectivity of the insular cortex in individuals with fibromyalgia. J Pain 15:815-826.e1
Napadow, Vitaly; Kim, Jieun; Clauw, Daniel J et al. (2012) Decreased intrinsic brain connectivity is associated with reduced clinical pain in fibromyalgia. Arthritis Rheum 64:2398-403
Napadow, Vitaly; LaCount, Lauren; Park, Kyungmo et al. (2010) Intrinsic brain connectivity in fibromyalgia is associated with chronic pain intensity. Arthritis Rheum 62:2545-55
Napadow, Vitaly; Dhond, Rupali P; Kim, Jieun et al. (2009) Brain encoding of acupuncture sensation--coupling on-line rating with fMRI. Neuroimage 47:1055-65
Hsu, Michael C; Harris, Richard E; Sundgren, Pia C et al. (2009) No consistent difference in gray matter volume between individuals with fibromyalgia and age-matched healthy subjects when controlling for affective disorder. Pain 143:262-7
Harris, Richard E; Sundgren, Pia C; Craig, A D et al. (2009) Elevated insular glutamate in fibromyalgia is associated with experimental pain. Arthritis Rheum 60:3146-52
Harris, Richard E; Zubieta, Jon-Kar; Scott, David J et al. (2009) Traditional Chinese acupuncture and placebo (sham) acupuncture are differentiated by their effects on mu-opioid receptors (MORs). Neuroimage 47:1077-85
Napadow, Vitaly; Ahn, Andrew; Longhurst, John et al. (2008) The status and future of acupuncture mechanism research. J Altern Complement Med 14:861-9
Harris, Richard E; Sundgren, Pia C; Pang, Yuxi et al. (2008) Dynamic levels of glutamate within the insula are associated with improvements in multiple pain domains in fibromyalgia. Arthritis Rheum 58:903-7

Showing the most recent 10 out of 16 publications