Childhood adversity is remarkably prevalent and significantly increases the risk of developing psychiatric symptoms during adulthood, especially depression and anxiety. Preclinical studies found that early-life stress induces excessive release of stress hormones which inhibit neuronal growth, particularly in the hippocampus. Recent research from M. Teicher et al. found that young adults with childhood maltreatment have smaller hippocampal subfield volumes compared to age- and education-matched controls that did not have childhood maltreatment. Studies from S. Lazar et al. found that the Mindfulness-Based Stress Reduction (MBSR) program is associated with increased hippocampal gray matter density. With the co-mentorship from Drs. Teicher and Lazar, the objective of the proposed research is to evaluate the effect of MBSR in reducing the depression and anxiety symptoms in young adults with childhood adversity, as well as for inducing hippocampal structural and functional changes. There are three specific aims focused on achieving this objective:
(Aim 1) : To examine changes in perceived stress and clinical symptoms after MBSR.
(Aim 2) : To investigate hippocampal structural and functional changes after MBSR, and how they are related to stress reduction and clinical effects.
(Aim 3) : To analyze changes of hippocampal functional connectivity in the global neural network. This study will improve our understanding about the clinical and neural effects of MBSR for young adults with childhood adversity.

Public Health Relevance

This research project will investigate the effects of a mindfulness-based program for young adults with childhood adversity including reduction of stress, depression and anxiety symptoms, as well as changes in hippocampus structure and function. This research project will increase our knowledge about the neural mechanisms of mindfulness in this population.

Agency
National Institute of Health (NIH)
Institute
National Center for Complementary & Alternative Medicine (NCCAM)
Type
Research Scientist Development Award - Research & Training (K01)
Project #
5K01AT009085-04
Application #
9688189
Study Section
Special Emphasis Panel (ZAT1)
Program Officer
Sabri, Merav
Project Start
2016-05-01
Project End
2021-04-30
Budget Start
2019-05-01
Budget End
2020-04-30
Support Year
4
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Mclean Hospital
Department
Type
DUNS #
046514535
City
Belmont
State
MA
Country
United States
Zip Code
02478