) Management of brain and head and neck cancer is one of the great therapeutic dilemmas of modern medicine. The problem is compounded by a lack of well-defined tumor risk factors and the inaccuracies in pretreatment staging. Traditional diagnostic imaging modalities are focused mainly on defining the anatomic lesion and are unable to provide information about the various physiological and functional factors that affect malignancy. The purpose of this research project is to determine the appropriate role of MR physiological techniques in the clinical management of patients with brain, head and neck cancer based on the outcome measure of progression-free survival. The proposed research is designed to further develop new imaging techniques in the brain and head and neck (rCBV, Diffusion) and evaluate these and other more established imaging methods (MRSI, MRI) by comparison with histopathology and to evaluate the potential of the measured physiological parameters to provide prognostic indicators of response to radiotherapy.
Study aims i nclude: 1) to develop and improve pulse sequences and quantification of rCBV and diffusion in the brain, and perfusion, diffusion, and 1H MRSI in the head and neck; 2) validate these techniques by comparison of measurements to histopathology in untreated cerebral gliomas and diseased lymph nodes of patients with squamous cell carcinoma of the head and neck; 3) investigate the role of the physiological properties measured by these techniques to provide early and late indicators of response to radiotherapy for cerebral gliomas and lymph nodes involved in squamous cell carcinoma of the head and neck. It is anticipated that results from the proposed research will help develop a single clinical imaging examination that will provide conventional MRI as well as the added physiological and functional information obtained with these techniques, some of which would normally require invasive biopsy procedures. Moreover, the candidate expects that the correlation of these physiological parameters and anatomical MRI will improve characterization of cancers of the brain and head and neck. While this study is anticipated to provide new information specific to cerebral gliomas and head and neck carcinomas, since these techniques measure physiological and functional characteristics, these results may provide further insight into the mechanisms and physiology of all human cancer.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Scientist Development Award - Research & Training (K01)
Project #
5K01CA076998-04
Application #
6173439
Study Section
Special Emphasis Panel (ZCA1-CRB-X (O1))
Program Officer
Locke, Belinda
Project Start
1997-09-30
Project End
2002-09-29
Budget Start
2000-09-30
Budget End
2001-09-29
Support Year
4
Fiscal Year
2000
Total Cost
$158,667
Indirect Cost
Name
University of California San Francisco
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Catalaa, Isabelle; Henry, Roland; Dillon, William P et al. (2006) Perfusion, diffusion and spectroscopy values in newly diagnosed cerebral gliomas. NMR Biomed 19:463-75
Oh, Joonmi; Henry, Roland G; Pirzkall, Andrea et al. (2004) Survival analysis in patients with glioblastoma multiforme: predictive value of choline-to-N-acetylaspartate index, apparent diffusion coefficient, and relative cerebral blood volume. J Magn Reson Imaging 19:546-54
Berman, Jeffrey I; Berger, Mitchel S; Mukherjee, Pratik et al. (2004) Diffusion-tensor imaging-guided tracking of fibers of the pyramidal tract combined with intraoperative cortical stimulation mapping in patients with gliomas. J Neurosurg 101:66-72
Henry, Roland G; Berman, Jeffrey I; Nagarajan, Srikantan S et al. (2004) Subcortical pathways serving cortical language sites: initial experience with diffusion tensor imaging fiber tracking combined with intraoperative language mapping. Neuroimage 21:616-22
Fischbein, Nancy J; Noworolski, Susan M; Henry, Roland G et al. (2003) Assessment of metastatic cervical adenopathy using dynamic contrast-enhanced MR imaging. AJNR Am J Neuroradiol 24:301-11
Noworolski, Susan M; Fischbein, Nancy J; Kaplan, Michael J et al. (2003) Challenges in dynamic contrast-enhanced MRI imaging of cervical lymph nodes to detect metastatic disease. J Magn Reson Imaging 17:455-62
Srinivasan, Radhika; Henry, Roland; Pelletier, Daniel et al. (2003) Standardized, reproducible, high resolution global measurements of T1 relaxation metrics in cases of multiple sclerosis. AJNR Am J Neuroradiol 24:58-67
Gelal, F M; Grant, P E; Fischbein, N J et al. (2001) The role of isotropic diffusion MRI in children under 2 years of age. Eur Radiol 11:1006-14
Henry, R G; Vigneron, D B; Fischbein, N J et al. (2000) Comparison of relative cerebral blood volume and proton spectroscopy in patients with treated gliomas. AJNR Am J Neuroradiol 21:357-66