This proposal for a Mentored Research Scientist Award is designed to provide the candidate with training in the behavioral, environmental and neurobiological mechanisms underlying the transitions to drug use and dependence. The proposed career development plan will add new masteries of concepts, principles and methods from several branches of biobehavioral research on drug involvement. The long term goal is to establish the candidate as an independent investigator who will develop and tailor new biostatistical methods that lead to new understandings of transitions from the earliest stages of drug involvement onward to dependence, placing these transitions into context with other antecedent or co-occurring life circumstances, social contexts, and biobehavioral vulnerability traits. Several mentors with complimentary skills will advise the candidate during her career development. Primary sponsor Dr. James Anthony will advise the candidate's training in the area of drug use epidemiology. Cosponsor Dr. Michael Nader and consultant Dr. Kathleen Grant will advise the candidate's training in the area of neurobiology and biobehavioral research on drug abuse. Co-sponsor Dr. Mark Wolfson and consultant Dr. Nikolas Ialongo will advise the candidate's training in the area of community and classroom interventions, respectively. Dr. David Altman will provide assistance on drug abuse policy. Drs. Ken Dodge and Robert DuRant will provide assistance on aggressive and violent behaviors in the context of drug use. The candidate's research plan will focus on addressing gaps in knowledge related to the process by which youths make transitions from early exposure opportunities to later drug use. Consistent with the candidate's prior methodological work, the focus will be on the application and development of methods related to the study of behavior repertoires that are indicators of underlying and otherwise unmeasureable conditions. The candidate will use available data to address research questions that will serve as groundwork for an independent research program that will examine the evolution of drug behaviors and their links with both individual and contextual factors.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Scientist Development Award - Research & Training (K01)
Project #
5K01DA016279-04
Application #
7069098
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Lopez, Marsha
Project Start
2003-05-01
Project End
2008-04-30
Budget Start
2006-05-01
Budget End
2007-04-30
Support Year
4
Fiscal Year
2006
Total Cost
$145,385
Indirect Cost
Name
Wake Forest University Health Sciences
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
937727907
City
Winston-Salem
State
NC
Country
United States
Zip Code
27157
Reboussin, Beth A; Ialongo, Nicholas S (2010) Latent transition models with latent class predictors: attention deficit hyperactivity disorder subtypes and high school marijuana use. J R Stat Soc Ser A Stat Soc 173:145-164
Reboussin, Beth A; Ip, Edward H; Wolfson, Mark (2008) Locally dependent latent class models with covariates: an application to under-age drinking in the USA. J R Stat Soc Ser A Stat Soc 171:877-897
Martelle, Jennifer L; Claytor, Renee; Ross, Jason T et al. (2007) Effects of two novel D3-selective compounds, NGB 2904 [N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)-9H-fluorene-2-carboxamide] and CJB 090 [N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)-4-(pyridin-2-yl)benzamide], on the reinforcing and discrimin J Pharmacol Exp Ther 321:573-82
Preisser, John S; Reboussin, Beth A; Song, Eun-Young et al. (2007) The importance and role of intracluster correlations in planning cluster trials. Epidemiology 18:552-60
Reboussin, Beth A; Hubbard, Scott; Ialongo, Nicholas S (2007) Marijuana use patterns among African-American middle-school students: a longitudinal latent class regression analysis. Drug Alcohol Depend 90:12-24
Czoty, Paul W; Reboussin, Beth A; Calhoun, Tonya L et al. (2007) Long-term cocaine self-administration under fixed-ratio and second-order schedules in monkeys. Psychopharmacology (Berl) 191:287-95
Goldston, David B; Walsh, Adam; Mayfield Arnold, Elizabeth et al. (2007) Reading problems, psychiatric disorders, and functional impairment from mid- to late adolescence. J Am Acad Child Adolesc Psychiatry 46:25-32
Reboussin, Beth A; Song, Eun-Young; Shrestha, Anshu et al. (2006) A latent class analysis of underage problem drinking: evidence from a community sample of 16-20 year olds. Drug Alcohol Depend 83:199-209
Goldston, David B; Reboussin, Beth A; Daniel, Stephanie Sergent (2006) Predictors of suicide attempts: state and trait components. J Abnorm Psychol 115:842-9
Reboussin, Beth A; Anthony, James C (2006) Is there epidemiological evidence to support the idea that a cocaine dependence syndrome emerges soon after onset of cocaine use? Neuropsychopharmacology 31:2055-64

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