Black males exhibit a steeper escalation in substance use (i.e., cross-over effects) and experience disproportionately higher rates of correlated poor health outcomes (e.g., HIV-related deaths and homicide) and low educational attainment compared with White males during emerging adulthood (ages 18 to 29 years). 1-3 Neighborhoods have been identified as important contexts for investigating substance use during emerging adulthood. 4 Yet, there is a fundamental gap in the current scientific evidence-base about the role of neighborhood conditions, beyond those defined by census data, in shaping substance use for Black emerging adult males. An equally notable evidence gap is created by the limited number of studies focusing on mechanisms that could explain why some Black emerging adult males exposed to less optimal neighborhood conditions engage in problematic (vs. non-problematic) substance use (i.e., alcohol and marijuana). This K01 application, entitled Neighborhoods, daily stress, affect regulation, &Black male substance use proposes integrated training and research to address these gaps by assessing potential pathways linking directly-observed neighborhood violence, alcohol, and drug activity to problematic substance use among Black male emerging adults. The potential pathways include theory-supported stress- affective mechanisms: daily stress, stress and androgenic hormones (as assessed through biomarkers), and affect regulation. The central hypothesis, grounded in Phenomenological Variant of Ecological Systems Theory5, and psychobiological models of stress, coping, and risk-taking,6-8 is that neighborhoods with high violence, alcohol, and drug activity instigate problematic substance use through increased daily stress experiences leading in turn to higher negative affect, and dysregulated cortisol and testosterone. Moreover, when these stress response processes occur in tandem with affect regulation strategies that encourage 'stuffing down'negative affect (i.e., emotion suppression), the effect on problematic substance use is expected to be heightened. The studies will employ a sample of non-substance dependent, Black emerging adult males (n = 66) drawn from Durham, NC neighborhoods (i.e., census block groups). A variety of assessment and analytic methods will be used including neighborhood social observations, Ecological Momentary Assessments (EMA), salivary hormone biomarker analyses, and focus groups.
Three specific aims will be examined in two complementary studies: 1) to use the Neighborhood Inventory for Environmental Typology (NIfETy) 9, and Ecological Momentary Assessment (EMA) data to examine associations between neighborhood violence, alcohol, and drug activity (VAOD) and daily problematic alcohol and marijuana use;2) to investigate daily stress-affective mechanisms linking neighborhood VAOD to daily problematic alcohol and marijuana use;and 3) to develop tailored messages for a future ecological momentary intervention designed to modulate stress-affective processes in """"""""real-time."""""""" Dr. Powell Hammond, who is trained in clinical psychology and health behavior and health education, and has focused her research career on using community-based approaches to investigate stress, gender, and health disparities, particularly among Black males. Training activities will include: formal didactics and hands-on instruction in conducting systemic social observations of neighborhoods, EMA, and salivary bioscience methods, workshops on tailored message development and ecological momentary intervention design, bioethics and responsible conduct in research training, and attendance at national and international conferences. She has assembled a strong interdisciplinary mentoring team that will guide her training and career development plans for building new skills in substance abuse research, neighborhood epidemiological assessment and social observational methods, ecological momentary assessment/intervention design, salivary biomarker measurement and data collection, and statistical methods for analyzing complex longitudinal models. The K01 award will increase her capabilities as an independent researcher to develop and test a fully powered ecological momentary intervention, as a separate R-level proposal. Results of the proposed research will also enhance current understanding of neighborhood effects on problematic substance use in Black males, inform development of ecologically valid addiction and relapse prevention interventions, and ultimately help to reduce substance use cross-over effects and substance abuse-related morbidity and mortality among Black emerging males.

Public Health Relevance

The proposed research is relevant to public health because it seeks to clarify stress-affective mechanisms through which neighborhood conditions impact problematic alcohol and marijuana use during the transition to adulthood. The proposed research is also relevant to NIDA's strategic goal to prevent the initiation of drug use and the escalation to addiction in those who have already initiated use and relevant to NIDA's prevention objective to how genes, environment, and development influence the various risk and protective factors for drug abuse. Specifically, it will elucidate putative ecologic and affectve triggers that can be targeted in novel preventive interventions designed to deliver real-time substance abuse counterstrategies and reduce Black male premature substance abuse-related morbidity and mortality.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Research Scientist Development Award - Research & Training (K01)
Project #
Application #
Study Section
Community Influences on Health Behavior (CIHB)
Program Officer
Schulden, Jeffrey D
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of North Carolina Chapel Hill
Schools of Public Health
Chapel Hill
United States
Zip Code
Taggart, Tamara; Gottfredson, Nisha; Powell, Wizdom et al. (2018) The Role of Religious Socialization and Religiosity in African American and Caribbean Black Adolescents' Sexual Initiation. J Relig Health 57:1889-1904
Fleming, Paul J; Barrington, Clare; Powell, Wizdom et al. (2018) The Association Between Men's Concern About Demonstrating Masculine Characteristics and Their Sexual Risk Behaviors: Findings from the Dominican Republic. Arch Sex Behav 47:507-515
Rosen, David L; Grodensky, Catherine A; Miller, Anna R et al. (2018) Implementing a Prison Medicaid Enrollment Program for Inmates with a Community Inpatient Hospitalization. J Urban Health 95:149-158
Adimora, Adaora A; Schoenbach, Victor J; Cates, Joan R et al. (2017) Changing Attitudes About Concurrency Among Young African Americans: Results of a Radio Campaign. AIDS Educ Prev 29:330-346
Mattis, Jacqueline S; Powell, Wizdom; Grayman, Nyasha A et al. (2017) What Would I Know About Mercy? Faith and Optimistic Expectancies Among African Americans. Race Soc Probl 9:42-52
Adams, Leslie B; Richmond, Jennifer; Corbie-Smith, Giselle et al. (2017) Medical Mistrust and Colorectal Cancer Screening Among African Americans. J Community Health 42:1044-1061
Chae, David H; Powell, Wizdom A; Nuru-Jeter, Amani M et al. (2017) The Role of Racial Identity and Implicit Racial Bias in Self-Reported Racial Discrimination: Implications for Depression Among African American Men. J Black Psychol 43:789-812
Richmond, Jennifer; Powell, Wizdom; Maurer, Maureen et al. (2017) Public Mistrust of the U.S. Health Care System's Profit Motives: Mixed-Methods Results from a Randomized Controlled Trial. J Gen Intern Med 32:1396-1402
Powell, Wizdom; Banks, Kira Hudson; Mattis, Jacqueline S (2017) Buried hatchets, marked locations: Forgiveness, everyday racial discrimination, and African American men's depressive symptomatology. Am J Orthopsychiatry 87:646-662
Powell, Wizdom; Adams, Leslie B; Cole-Lewis, Yasmin et al. (2016) Masculinity and Race-Related Factors as Barriers to Health Help-Seeking Among African American Men. Behav Med 42:150-63

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