Candidate ? Immediate and Long-Term Career Goals: Jung Yeon Lee, Ph.D., has a strong background in statistics and behavioral science, as well as basic and translational research. Her overarching career goal is to become an independent academic research scientist working at the interface between substance use, psychopathology, cultural factors, intervention research, and statistics. To achieve this long term goal, Dr. Lee plans to extend her research area into the social sciences through a plan for acquiring epidemiological expertise, and developing innovative statistical techniques to deal with large longitudinal datasets. Environment ? Key Elements of the Research Career Development Plan: Dr. Lee is currently a junior research member in the Department of Psychiatry at New York University School of Medicine. Under the guidance of her mentoring team (Drs. J.S. Brook, S.J. Finch, D.W. Brook), collaborators (Drs. M. Galanter, J. Endicott, K. Pahl, E. Obasi, M. De La Rosa), she will enter a rigorous training program consisting of: 1) formal didactic training via graduate courses (Departments of Environmental Medicine, Psychiatry, and Psychology); 2) research training via attending seminars and meetings; 3) contribution to journal clubs and group meetings in the research groups of the mentors and collaborators; 4) participation in national international conferences and symposia; and 5) participation in training courses in the responsible conduct of research. Research Project: This revised grant application, based on a 20-year longitudinal study of African Americans and Puerto Ricans, is designed to 1) identify the predictors and consequences (e.g., psychiatric disorders) of triple comorbid trajectories of substance use; 2) investigate the pathways from cultural factors and parent-child attachment in adolescence to substance use in adulthood; and 3) inform intervention research to be more effective for African American and Puerto Rican adolescents and adults. In addition, the research will serve as the foundation for a future study to be written in years 4 and 5 on examining the differences and/or similarities in the patterns of substance use as well as adverse outcomes from substance use between monoracial and biracial Black/Hispanic individuals. This research is in response to NIDAs call for studies of African American and Hispanic individuals. Of importance, the objectives of my career development plan include the following: 1) become an expert in using advanced analytic techniques such as growth mixture modeling, structural equation modeling, and propensity score analysis; 2) acquire expertise in cultural factors and substance use disorders; 3) develop interdisciplinary collaborations; 4) disseminate research findings; and 5) grant development. Relevance: The findings will lead to a greater understanding of the relationships between triple comorbid trajectories of substance use and 1) psychological functioning in adolescence as predictors and 2) in adulthood as consequences. The results will also lead to further knowledge of the risk and protective factors of substance use. These findings would contribute to innovative prevention and treatment programs.

Public Health Relevance

The significance of the proposed study lies in its potential to: a) identify the predictors and consequences of triple trajectories of comorbid substance use; b) examine the developmental pathways to substance use; and c) inform intervention research. This investigation employs state-of-the-art analytic methods and has the possibility to provide significant knowledge regarding the patterns and concomitants of substance use. Such knowledge has important implications for the type and timing of innovative diagnostic tests, treatments, and public health.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Research Scientist Development Award - Research & Training (K01)
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Addiction Risks and Mechanisms Study Section (ARM)
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Etz, Kathleen
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New York University
Schools of Medicine
New York
United States
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Lee, Jung Yeon; Brook, Judith S; Pahl, Kerstin et al. (2018) Sexual risk behaviors in African American and Puerto Rican women: Impulsivity and self-control. Prev Med Rep 10:218-220
Lee, Jung Yeon; Brook, Judith S; Finch, Stephen J et al. (2018) Trajectories of cannabis use beginning in adolescence associated with symptoms of posttraumatic stress disorder in the mid-thirties. Subst Abus 39:39-45
Lee, Jung Yeon; Brook, Judith S; Pahl, Kerstin (2018) Human Immunodeficiency Virus (HIV) Risk Behaviors by African American and Puerto Rican Women in the 4th Decade of Life: Substance Use and Personal Attributes. J Prev Med (Wilmington) 3:
Lee, Jung Yeon; Brook, Judith S; Kim, Wonkuk (2018) Triple trajectories of alcohol use, tobacco use, and depressive symptoms as predictors of cannabis use disorders among urban adults. Psychol Addict Behav 32:466-474
Lee, Jung Yeon; Brook, Judith S; Pahl, Kerstin et al. (2017) Substance Use and the Number of Male Sex Partners by African American and Puerto Rican Women. J Community Health Res 6:192-196
Lee, Jung Yeon; Brook, Judith S; Finch, Stephen J et al. (2017) Joint trajectories of cigarette smoking and depressive symptoms from the mid-20s to the mid-30s predicting generalized anxiety disorder. J Addict Dis 36:158-166
Lee, Jung Yeon; Brook, Judith S; Pahl, Kerstin et al. (2017) Longitudinal pathways from unconventional personal attributes in the late 20s to cannabis use prior to sexual intercourse in the late 30s. Addict Behav 74:148-152