Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Scientist Development Award - Research & Training (K01)
Project #
7K01DK062894-03
Application #
6936243
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Podskalny, Judith M,
Project Start
2003-03-01
Project End
2005-11-30
Budget Start
2004-08-16
Budget End
2004-11-30
Support Year
3
Fiscal Year
2004
Total Cost
$39,791
Indirect Cost
Name
Georgia State University
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
837322494
City
Atlanta
State
GA
Country
United States
Zip Code
30302
Zen, Ke; Guo, Yalan; Bian, Zhen et al. (2013) Inflammation-induced proteolytic processing of the SIRP? cytoplasmic ITIM in neutrophils propagates a proinflammatory state. Nat Commun 4:2436
Bian, Zhen; Guo, YaLan; Ha, Binh et al. (2012) Regulation of the inflammatory response: enhancing neutrophil infiltration under chronic inflammatory conditions. J Immunol 188:844-53
Zen, Ke; Liu, Yuan (2008) Role of different protein tyrosine kinases in fMLP-induced neutrophil transmigration. Immunobiology 213:13-23
Liu, Yuan; Tong, Qiao; Zhou, Yubin et al. (2007) Functional elements on SIRPalpha IgV domain mediate cell surface binding to CD47. J Mol Biol 365:680-93
Zen, Ke; Chen, Celia X-J; Chen, Yi-Tien et al. (2007) Receptor for advanced glycation endproducts mediates neutrophil migration across intestinal epithelium. J Immunol 178:2483-90
Zen, Ke; Reaves, Titus A; Soto, Ileana et al. (2006) Response to genistein: assaying the activation status and chemotaxis efficacy of isolated neutrophils. J Immunol Methods 309:86-98
Zen, Ke; Liu, Yuan; McCall, Ingrid C et al. (2005) Neutrophil migration across tight junctions is mediated by adhesive interactions between epithelial coxsackie and adenovirus receptor and a junctional adhesion molecule-like protein on neutrophils. Mol Biol Cell 16:2694-703
Liu, Yuan; Soto, Ileana; Tong, Qiao et al. (2005) SIRPbeta1 is expressed as a disulfide-linked homodimer in leukocytes and positively regulates neutrophil transepithelial migration. J Biol Chem 280:36132-40
Liu, Yuan; O'Connor, Miriam B; Mandell, Kenneth J et al. (2004) Peptide-mediated inhibition of neutrophil transmigration by blocking CD47 interactions with signal regulatory protein alpha. J Immunol 172:2578-85
Liu, Yuan; Shaw, Sunil K; Ma, Shuo et al. (2004) Regulation of leukocyte transmigration: cell surface interactions and signaling events. J Immunol 172:7-13

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