We have reached a new era in genetics and epidemiology where resources to study key questions related to genetics, environment, and disease are widely available to the greater research community. However, few researchers have the expertise needed to exploit these resources to their full potential, The aims of this proposal are two-fold: 1) to provide didactic training and mentorship in the fields of genetics and metabolic disorders to a young investigator with burgeoning expertise in the areas of nutrition and cardiovascular disease epidemiology, and 2) to answer key questions related to the collective influence of genetics and diet on type 2 diabetes (T2D) with the long term goal of developing a research program that will continue to strategically chip away the layers of complexity that exist in this area of research. Recent advances in genetic research have lead to the discovery of regions of common genetic variation that are associated withT2D risk and portend a potentially substantial impact at the population level. The next step is to determine the best course of action for individuals at high genetic risk. Holistic representations of dietary intake, specifically, intakes of particular food groups and dietary patterns, play an important role in the development of T2D. However, we have not thoroughly explored how these associations operate in persons with a high genetic risk for T2D. Many of the pathways by which diet is thought to influence T2D risk are complimentary to those thought to be modulated by genetic variation. The goal of the proposed research is to determine whether dietary factors currently known to influence risk of T2D in the general population modify associations between genotype and T2D by modulating complimentary metabolic pathways influenced by genetic variation. We will achieve this goal by studying interactions between genetic variation and foods known to influence T2D risk, as well as interactions between genetic variation and dietary patterns known to influence T2D risk. This project will utilize data from three cohorts included in the Candidate gene Association Resource (CARe): the Multi-Ethnic Study of Atherosclerosis (MESA), the Atherosclerosis Risk in Communities (ARIC) study, and the Coronary Artery disease Risk In young Adults (CARDIA) study.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Scientist Development Award - Research & Training (K01)
Project #
5K01DK082729-02
Application #
7687564
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Hyde, James F
Project Start
2008-09-15
Project End
2012-08-31
Budget Start
2009-09-01
Budget End
2010-08-31
Support Year
2
Fiscal Year
2009
Total Cost
$107,341
Indirect Cost
Name
University of Texas Health Science Center Houston
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
800771594
City
Houston
State
TX
Country
United States
Zip Code
77225
McKeown, Nicola M; Dashti, Hassan S; Ma, Jiantao et al. (2018) Sugar-sweetened beverage intake associations with fasting glucose and insulin concentrations are not modified by selected genetic variants in a ChREBP-FGF21 pathway: a meta-analysis. Diabetologia 61:317-330
Nettleton, Jennifer A; Follis, Jack L; Ngwa, Julius S et al. (2015) Gene × dietary pattern interactions in obesity: analysis of up to 68 317 adults of European ancestry. Hum Mol Genet 24:4728-38
Zheng, Yan; Yu, Bing; Alexander, Danny et al. (2014) Metabolomic patterns and alcohol consumption in African Americans in the Atherosclerosis Risk in Communities Study. Am J Clin Nutr 99:1470-8
Guan, Weihua; Steffen, Brian T; Lemaitre, Rozenn N et al. (2014) Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium. Circ Cardiovasc Genet 7:321-331
Shea, M K; Cushman, M; Booth, S L et al. (2014) Associations between vitamin K status and haemostatic and inflammatory biomarkers in community-dwelling adults. The Multi-Ethnic Study of Atherosclerosis. Thromb Haemost 112:438-44
Yu, Bing; Zheng, Yan; Nettleton, Jennifer A et al. (2014) Serum metabolomic profiling and incident CKD among African Americans. Clin J Am Soc Nephrol 9:1410-7
Mozaffarian, Dariush; de Oliveira Otto, Marcia C; Lemaitre, Rozenn N et al. (2013) trans-Palmitoleic acid, other dairy fat biomarkers, and incident diabetes: the Multi-Ethnic Study of Atherosclerosis (MESA). Am J Clin Nutr 97:854-61
Zheng, Yan; Yu, Bing; Alexander, Danny et al. (2013) Metabolomics and incident hypertension among blacks: the atherosclerosis risk in communities study. Hypertension 62:398-403
Yu, Bing; Zheng, Yan; Alexander, Danny et al. (2013) Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study. Genet Epidemiol 37:840-5
Zheng, Yan; Yu, Bing; Alexander, Danny et al. (2013) Associations between metabolomic compounds and incident heart failure among African Americans: the ARIC Study. Am J Epidemiol 178:534-42

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