(provided by candidate): The purpose of this proposal is to provide a means for the applicant, Dana Peters, to develop as an independent scientist and leader in cardiovascular MR using the radial acquisition method. This proposal provides her with two mentors, a cardiologist recognized for his MR contributions, and a MR physicist for his work in cardiovascular research, and support from the Cardiology Division of Beth Israel Deaconess Medical Center. The career development plan describes a path by which to obtain the goal of becoming a leader in cardiovascular MR, focusing in the areas of image processing, cardiovascular medicine, and statistics. To date, her focus has been on undersampled radial imaging for fast and high-resolution applications. The research proposal details the development of an undersampled 3D radial (slice-encodings and projections in x-y plane) sequence for cardiac function and viability. This work focuses on the development, refinement, and validation in patient populations of this method. The value of the 3D method is its complete coverage of the heart, for example during a stress test, its completion in a single breath-hold compared to 10 breath holds for the 2D approach, and potentially higher SNR of 3D compared with 2D. First the basic ecg-gated segmented 3D radial method will be refined to remove artifacts due to the radial acquisition, especially in the presence of off-resonance, flow, and SSFP contrast. Then newly developed undersampling artifact reduction techniques will be used to improve image quality of highly undersampled methods. Respiratory gated imaging will also be investigated. For myocardial function, 3D methods will be compared to 2D methods to validate left ventricular mass, volumes, and regional wall thickening values. A T1-weighted single phase viability sequence will be developed. Development will focus on increasing spatial resolution, improving contrast between infarcted and remote myocardium, and reducing artifacts from signal regrowth. The high resolution 3D radial viability technique will be validated in animals, and also used in patients.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Research Scientist Development Award - Research & Training (K01)
Project #
5K01EB004434-04
Application #
7460676
Study Section
Special Emphasis Panel (ZEB1-OSR-B (M1))
Program Officer
Erim, Zeynep
Project Start
2005-08-01
Project End
2010-06-30
Budget Start
2008-07-01
Budget End
2009-06-30
Support Year
4
Fiscal Year
2008
Total Cost
$117,123
Indirect Cost
Name
Beth Israel Deaconess Medical Center
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02215
Santelli, Claudio; Nezafat, Reza; Goddu, Beth et al. (2011) Respiratory bellows revisited for motion compensation: preliminary experience for cardiovascular MR. Magn Reson Med 65:1097-102
Meng, Joyce; Peters, Dana C; Hsing, Jeffrey M et al. (2010) Late gadolinium enhancement of the esophagus is common on cardiac MR several months after pulmonary vein isolation: preliminary observations. Pacing Clin Electrophysiol 33:661-6
Han, Yuchi; Peters, Dana C; Kissinger, Kraig V et al. (2010) Evaluation of papillary muscle function using cardiovascular magnetic resonance imaging in mitral valve prolapse. Am J Cardiol 106:243-8
Taclas, Jason E; Nezafat, Reza; Wylie, John V et al. (2010) Relationship between intended sites of RF ablation and post-procedural scar in AF patients, using late gadolinium enhancement cardiovascular magnetic resonance. Heart Rhythm 7:489-96
Peters, Dana C; Appelbaum, Evan A; Nezafat, Reza et al. (2009) Left ventricular infarct size, peri-infarct zone, and papillary scar measurements: A comparison of high-resolution 3D and conventional 2D late gadolinium enhancement cardiac MR. J Magn Reson Imaging 30:794-800
Han, Yuchi; Peters, Dana C; Dokhan, Basem et al. (2009) Shorter difference between myocardium and blood optimal inversion time suggests diffuse fibrosis in dilated cardiomyopathy. J Magn Reson Imaging 30:967-72
Peters, Dana C; Wylie, John V; Hauser, Thomas H et al. (2009) Recurrence of atrial fibrillation correlates with the extent of post-procedural late gadolinium enhancement: a pilot study. JACC Cardiovasc Imaging 2:308-16
Peters, Dana C; Nezafat, Reza; Eggers, Holger et al. (2008) 2D free-breathing dual navigator-gated cardiac function validated against the 2D breath-hold acquisition. J Magn Reson Imaging 28:773-7
Hauser, Thomas H; Peters, Dana C; Wylie, John V et al. (2008) Evaluating the left atrium by magnetic resonance imaging. Europace 10 Suppl 3:iii22-7
Peters, Dana C; Wylie, John V; Hauser, Thomas H et al. (2007) Detection of pulmonary vein and left atrial scar after catheter ablation with three-dimensional navigator-gated delayed enhancement MR imaging: initial experience. Radiology 243:690-5