The Mentored Research Scientist Development Award In Molecular Epidemiology is requested to support the career development of Dr. Susan Teitelbaum, who is a classically trained cancer epidemiologist. The primary aim of the K01 grant is to position Dr. Teitelbaum as an independent research scientist specializing in the environmental and molecular epidemiology of combined effects of multiple exposures.
The research aims, relating multiple xenoestrogen exposure to breast cancer risk, will be examined in the Long Island Breast Cancer Study Project, a large population-based case-control study of breast cancer and the environment. Traditional chronic disease epidemiology focuses on single risk factor-disease associations at the individual level with little consideration of the combined effect of multiple exposures, particularly those of similar biological action. Dr. Teitelbaum's career goal is to advance beyond the investigation of single exposure-disease relationships by incorporating advanced data analytic approaches not yet commonly used in epidemiology. Her training program will enable her to acquire in-depth knowledge of advanced statistical methods for examining the combined effect of multiple exposures and gene-environment interactions, a better understanding of the laboratory methods used to assess biomarkers of xenoestrogen exposure, and experience in working with genetic polymorphisms. The training program includes obtaining a Master's degree in biostatistics, laboratory rotations, and attendance at carefully chosen symposia and national meetings. Dr. Teitelbaum's proposal is sponsored by Dr. Mary Wolff (environmental/molecular epidemiology), Dr. Gertrud Berkowitz (epidemiology), and Dr. Sylvan Wallenstein (biostatistics). Additional advisors will be Drs. James Wetmur (environmental genetics) and Avrom Caplan (nuclear receptors). Breast cancer is an estrogen-related disease and xenoestrogens are strongly suspected to be environmental risk factors for breast cancer. With the exception of organochlorine compounds (including DDT, DDE and PCBs), little research has been directed at these environmental chemicals and even less has been focused on the combined effect of these hormonally active agents. Results of the proposed research project will be of enormous public health relevance since they may advance our knowledge of modifiable breast cancer risk factors, thereby providing information that is essential for primary prevention. Furthermore, data analysis approaches applied in this research project will be applicable to a wide range of environmentally associated diseases.

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Research Scientist Development Award - Research & Training (K01)
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Study Section
Environmental Health Sciences Review Committee (EHS)
Program Officer
Shreffler, Carol K
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Mount Sinai School of Medicine
Public Health & Prev Medicine
Schools of Medicine
New York
United States
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Parada Jr, Humberto; Gammon, Marilie D; Chen, Jia et al. (2018) Urinary Phthalate Metabolite Concentrations and Breast Cancer Incidence and Survival following Breast Cancer: The Long Island Breast Cancer Study Project. Environ Health Perspect 126:047013
Sheffield, Perry E; Uijttewaal, Simone A M; Stewart, James et al. (2017) Climate Change and Schools: Environmental Hazards and Resiliency. Int J Environ Res Public Health 14:
Vangeepuram, N; Galvez, M P; Teitelbaum, S L et al. (2012) The association between parental perception of neighborhood safety and asthma diagnosis in ethnic minority urban children. J Urban Health 89:758-68
Vangeepuram, Nita; Mervish, Nancy; Galvez, Maida P et al. (2012) Dietary and physical activity behaviors of New York City children from different ethnic minority subgroups. Acad Pediatr 12:481-8
Teitelbaum, Susan L; Mervish, Nancy; Moshier, Erin L et al. (2012) Associations between phthalate metabolite urinary concentrations and body size measures in New York City children. Environ Res 112:186-93
Mervish, Nancy; Blount, Ben; Valentin-Blasini, Liza et al. (2012) Temporal variability in urinary concentrations of perchlorate, nitrate, thiocyanate and iodide among children. J Expo Sci Environ Epidemiol 22:212-8
Vangeepuram, Nita; Teitelbaum, Susan L; Galvez, Maida P et al. (2011) Measures of obesity associated with asthma diagnosis in ethnic minority children. J Obes 2011:517417
Wolff, Mary S; Teitelbaum, Susan L; Pinney, Susan M et al. (2010) Investigation of relationships between urinary biomarkers of phytoestrogens, phthalates, and phenols and pubertal stages in girls. Environ Health Perspect 118:1039-46
Lee, Yin Leng; Teitelbaum, Susan; Wolff, Mary S et al. (2010) Comparing genetic ancestry and self-reported race/ethnicity in a multiethnic population in New York City. J Genet 89:417-23
Biro, Frank M; Galvez, Maida P; Greenspan, Louise C et al. (2010) Pubertal assessment method and baseline characteristics in a mixed longitudinal study of girls. Pediatrics 126:e583-90

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