The primary objective of this KO1 Mentored Research Scientist Development Award application is to allow the candidate the opportunity to pursue an independent research career in medical rehabilitation research. The candidate has experience as an Occupational Therapist and has doctoral and postdoctoral training in the field of motor control. The candidate's long-term objective is to create an independent line of research that contributes to the understanding of mechanisms of locomotion and its recovery in individuals with MS. The short-term career goals are to test the association between pathologically relevant white matter damage, impairment measures and patterns of locomotion following an acute episode in multiple sclerosis (MS). These associations are critical to our understanding of how neuropathology and functional mobility are related and will further develop our understanding of the mechanisms involved in the recovery of locomotion. The proposed career development plan includes specific training to learn 1) the pathophysiology, treatment and rehabilitation of MS, 2) diffusion tensor imaging and magnetization transfer imaging analyses, 3) analyses of gait ataxia, and 4) design, statistical analyses, and execution of clinical studies.
The specific aims of the proposed studies will test the general hypothesis that, in MS and following an acute exacerbation the pattern of white matter damage is predictive of locomotor recovery. The proposed studies will investigate: 1) whether specific white matter tract abnormalities that occur following an acute exacerbation of MS correlate with specific sensorimotor impairments and features of walking patterns, and 2) whether damage to specific white matter tracts (i.e., the corticospinal, dorsal column medial lemniscal and cerebellar tracts) can predict the recovery of locomotion after a relapse of MS. These studies will incorporate measures of diffusion tensor imaging and magnetization transfer MRI for the evaluation of white matter integrity;in addition, the PIs will evaluate sensorimotor impairments of sensation, strength, spasticity, and ataxia, and relate these to locomotor function. Results of the proposed studies will, for the first time, provide important insights into neural mechanisms of locomotion, as well as the role of specific white matter fiber tracts in the recovery of locomotion in people with multiple sclerosis.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Research Scientist Development Award - Research & Training (K01)
Project #
Application #
Study Section
Pediatrics Subcommittee (CHHD)
Program Officer
Shinowara, Nancy
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Hugo W. Moser Research Institute Kennedy Krieger
United States
Zip Code
Fritz, Nora E; Eloyan, Ani; Baynes, Moira et al. (2018) Distinguishing among multiple sclerosis fallers, near-fallers and non-fallers. Mult Scler Relat Disord 19:99-104
Zackowski, Kathleen M; Wang, Joseph I; McGready, John et al. (2015) Quantitative sensory and motor measures detect change overtime and correlate with walking speed in individuals with multiple sclerosis. Mult Scler Relat Disord 4:67-74
Fritz, Nora E; Marasigan, Rhul Evans R; Calabresi, Peter A et al. (2015) The impact of dynamic balance measures on walking performance in multiple sclerosis. Neurorehabil Neural Repair 29:62-9
Fritz, Nora E; Newsome, Scott D; Eloyan, Ani et al. (2015) Longitudinal relationships among posturography and gait measures in multiple sclerosis. Neurology 84:2048-56
Oh, Jiwon; Zackowski, Kathleen; Chen, Min et al. (2013) Multiparametric MRI correlates of sensorimotor function in the spinal cord in multiple sclerosis. Mult Scler 19:427-35
Shiee, Navid; Bazin, Pierre-Louis; Zackowski, Kathleen M et al. (2012) Revisiting brain atrophy and its relationship to disability in multiple sclerosis. PLoS One 7:e37049
Newsome, Scott D; Wang, Joseph I; Kang, Jonathan Y et al. (2011) Quantitative measures detect sensory and motor impairments in multiple sclerosis. J Neurol Sci 305:103-11
Morton, Susanne M; Tseng, Ya-Weng; Zackowski, Kathleen M et al. (2010) Longitudinal tracking of gait and balance impairments in cerebellar disease. Mov Disord 25:1944-52
Zackowski, Kathleen M; Smith, Seth A; Reich, Daniel S et al. (2009) Sensorimotor dysfunction in multiple sclerosis and column-specific magnetization transfer-imaging abnormalities in the spinal cord. Brain 132:1200-9