The primary objective of this KO1 Mentored Research Scientist Development Award application is to allow the candidate the opportunity to pursue an independent research career in medical rehabilitation research. The candidate has experience as an Occupational Therapist and has doctoral and postdoctoral training in the field of motor control. The candidate's long-term objective is to create an independent line of research that contributes to the understanding of mechanisms of locomotion and its recovery in individuals with MS. The short-term career goals are to test the association between pathologically relevant white matter damage, impairment measures and patterns of locomotion following an acute episode in multiple sclerosis (MS). These associations are critical to our understanding of how neuropathology and functional mobility are related and will further develop our understanding of the mechanisms involved in the recovery of locomotion. The proposed career development plan includes specific training to learn 1) the pathophysiology, treatment and rehabilitation of MS, 2) diffusion tensor imaging and magnetization transfer imaging analyses, 3) analyses of gait ataxia, and 4) design, statistical analyses, and execution of clinical studies.
The specific aims of the proposed studies will test the general hypothesis that, in MS and following an acute exacerbation the pattern of white matter damage is predictive of locomotor recovery. The proposed studies will investigate: 1) whether specific white matter tract abnormalities that occur following an acute exacerbation of MS correlate with specific sensorimotor impairments and features of walking patterns, and 2) whether damage to specific white matter tracts (i.e., the corticospinal, dorsal column medial lemniscal and cerebellar tracts) can predict the recovery of locomotion after a relapse of MS. These studies will incorporate measures of diffusion tensor imaging and magnetization transfer MRI for the evaluation of white matter integrity;in addition, the PIs will evaluate sensorimotor impairments of sensation, strength, spasticity, and ataxia, and relate these to locomotor function. Results of the proposed studies will, for the first time, provide important insights into neural mechanisms of locomotion, as well as the role of specific white matter fiber tracts in the recovery of locomotion in people with multiple sclerosis.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Scientist Development Award - Research & Training (K01)
Project #
5K01HD049476-05
Application #
7917447
Study Section
Pediatrics Subcommittee (CHHD)
Program Officer
Shinowara, Nancy
Project Start
2006-09-07
Project End
2011-08-31
Budget Start
2010-09-01
Budget End
2011-08-31
Support Year
5
Fiscal Year
2010
Total Cost
$98,957
Indirect Cost
Name
Hugo W. Moser Research Institute Kennedy Krieger
Department
Type
DUNS #
155342439
City
Baltimore
State
MD
Country
United States
Zip Code
21205
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Zackowski, Kathleen M; Wang, Joseph I; McGready, John et al. (2015) Quantitative sensory and motor measures detect change overtime and correlate with walking speed in individuals with multiple sclerosis. Mult Scler Relat Disord 4:67-74
Fritz, Nora E; Marasigan, Rhul Evans R; Calabresi, Peter A et al. (2015) The impact of dynamic balance measures on walking performance in multiple sclerosis. Neurorehabil Neural Repair 29:62-9
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