Abstract

This application is intended to provide training in statistical genetics, and the development of methods for genetic linkage and association analysis of multi4ocus (complex) traits. The applicant, Dr. Derek Gordon, has chosen Dr. Jurg Ott, a well-known and highly distinguished statistical geneticist, to act as mentor. The choice of Dr. Ott will help assure that Dr. Gordon is trained in the most current and vital topics related to statistical genetics today. Some of those topics, listed as specific aims in the Research Plan, are (I) the effects of errors in genetic data analysis, (2) adequacy of 24ocus analysis models for multi-locus traits (assuming errorless data), and (3) 2- locus analysis with errors. Such topics are of considerable importance to the medical community for the foreseeable future, since one of the main goals of the Human Genome Project is the mapping of genes for multi- locus traits and diseases. Dr. Gordon's career objectives are to become a scholar in biomedical research and to become a leading member of multi-disciplinary research teams that map genes for multi-locus diseases. To achieve these objectives, Dr. Gordon will work through a career development plan that focuses on coursework, laboratory work, data analyses, presentations of research at meetings, and education in responsible conduct of research.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Human Genome Research Institute (NHGRI)
Type
Research Scientist Development Award - Research & Training (K01)
Project #
5K01HG000055-04
Application #
6654442
Study Section
Ethical, Legal, Social Implications Review Committee (GNOM)
Program Officer
Brooks, Lisa
Project Start
2000-09-30
Project End
2005-08-31
Budget Start
2003-09-01
Budget End
2004-08-31
Support Year
4
Fiscal Year
2003
Total Cost
$90,404
Indirect Cost

  Institution

Name
Rockefeller University
Department
Biostatistics & Other Math Sci
Type
Other Domestic Higher Education
DUNS #
071037113
City
New York
State
NY
Country
United States
Zip Code
10065

  Publications

Williams, Tanya J; LaForge, K Steven; Gordon, Derek et al. (2007) Prodynorphin gene promoter repeat associated with cocaine/alcohol codependence. Addict Biol 12:496-502
Lee, Erica; Lendas, Katherine A; Chow, Selwyn et al. (2006) Disease relevant HLA class II alleles isolated by genotypic, haplotypic, and sequence analysis in North American Caucasians with pemphigus vulgaris. Hum Immunol 67:125-39
Miranda, Ana; Garcia, Jenny; Lopez, Carlos et al. (2006) Putative association of the carboxy-terminal PDZ ligand of neuronal nitric oxide synthase gene (CAPON) with schizophrenia in a Colombian population. Schizophr Res 82:283-5
Proudnikov, Dmitri; LaForge, K Steven; Hofflich, Heather et al. (2006) Association analysis of polymorphisms in serotonin 1B receptor (HTR1B) gene with heroin addiction: a comparison of molecular and statistically estimated haplotypes. Pharmacogenet Genomics 16:25-36
Ellis, Nathan A; Kirchhoff, Tomas; Mitra, Nandita et al. (2006) Localization of breast cancer susceptibility loci by genome-wide SNP linkage disequilibrium mapping. Genet Epidemiol 30:48-61
Barral, Sandra; Haynes, Chad; Levenstien, Mark A et al. (2005) Precision and type I error rate in the presence of genotype errors and missing parental data: a comparison between the original transmission disequilibrium test (TDT) and TDTae statistics. BMC Genet 6 Suppl 1:S150
De La Vega, Francisco M; Gordon, Derek; Su, Xiaoping et al. (2005) Power and sample size calculations for genetic case/control studies using gene-centric SNP maps: application to human chromosomes 6, 21, and 22 in three populations. Hum Hered 60:43-60
Chuang, Gary S; Martinez-Mir, Amalia; Geyer, Adam et al. (2005) Germline fumarate hydratase mutations and evidence for a founder mutation underlying multiple cutaneous and uterine leiomyomata. J Am Acad Dermatol 52:410-6
Gordon, Derek; Haynes, Chad; Blumenfeld, Jon et al. (2005) PAWE-3D: visualizing power for association with error in case-control genetic studies of complex traits. Bioinformatics 21:3935-7
Frishberg, Yaacov; Topaz, Orit; Bergman, Reuven et al. (2005) Identification of a recurrent mutation in GALNT3 demonstrates that hyperostosis-hyperphosphatemia syndrome and familial tumoral calcinosis are allelic disorders. J Mol Med 83:33-8

Showing the most recent 10 out of 31 publications