Abstract

Lymphoid interstitial pneumonitis (LIP) and diffuse infiltrative lymphocytosis syndrome (DILS) are HIV-related disorders associated with improved survival. An important feature which these two conditions share in common is marked infiltration of the lungs by CD8+t lymphocytes. A condition similar to LIP and DILS occurs in a substantial fraction of macaques experimentally inoculated with certain strains of simian immunodeficiency virus (SIV). Macaques with this condition also have an improved survival time. It is proposed to employ the SIV/macaque model of LIP/DILS to test the hypothesis that the pulmonary cell-mediated immune response in these conditions provide systemic immunologic benefit and retard disease progression.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Scientist Development Award - Research & Training (K01)
Project #
1K01HL003833-01
Application #
2646526
Study Section
Special Emphasis Panel (ZHL1-CSR-K (F1))
Project Start
1998-07-01
Project End
2003-06-30
Budget Start
1998-07-01
Budget End
1999-06-30
Support Year
1
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Pathology
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Gebremedhin, Debebe; Yamaura, Ken; Harder, David R (2008) Role of 20-HETE in the hypoxia-induced activation of Ca2+-activated K+ channel currents in rat cerebral arterial muscle cells. Am J Physiol Heart Circ Physiol 294:H107-20