This application is a request for a Mentored Career Award for Faculty at Minority Institutions that will allow the candidate to develop a long-term research program concerned with the relationship between socio- economic distress (SED) associated with disadvantaged minority group membership and chronic kidney disease (CKD), a major risk factor for cardiovascular disease (CVD). The primary goal of this research project is to develop and elaborate a model specifying how distressing social and economic environments are associated with psychosocial, behavioral, and biomedical risk factors that impact the prevalence of CKD among African Americans. This project proposal outlines a plan of career development and intensive research activities that will leverage already completed doctoral level research and training in the social sciences. Substantive courses in addition to intense topical workshops and seminars will provide a structured means to strengthen five core competencies (i. e., epidemiology, biostatistics, ethics, leadership, and scientific presentation) that are necessary to establish a program of research investigating how non-traditional, non-biomedical factors and traditional biomedical risk factors independently and collectively impact CKD among an at-risk population. The research proposed in this application has three specific aims. The proposed project will: 1) examine the extent to which socio-economic distress or SED is associated with CKD among African Americans: 2) assess the degree to which potentially mediating mechanisms are independently and collectively associated with CKD among African Americans; and 3) determine the extent to which the relationship between SED and CKD is mediated by psychosocial, behavioral, and biomedical factors. The models associated with each aim will be assessed through an innovative analysis of data from the Jackson Heart Study (JHS). The JHS is a longitudinal, population-based study of CVD and related risk factors among African Americans in Mississippi - the state with the worst health profile in the nation. The resources at Meharry Medical College, Vanderbilt University, and the JHS provide a unique setting for a five year program of mentored research, education, and training that will build on the candidate's background in the social sciences to produce cutting-edge epidemiological research focusing on health disparities, CKD, and CVD. This research will incorporate information about the context in which African Americans live and work into empirical models specifying how non-traditional (as well as traditional) biomedical risk factors impact health outcomes; thereby informing health policy's effort to address and eliminate CKD and CVD disparities. ? ? ?

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Research Scientist Development Award - Research & Training (K01)
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Special Emphasis Panel (ZHL1-CSR-H (F1))
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Nelson, Cheryl R
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Meharry Medical College
Family Medicine
Schools of Medicine
United States
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Bruce, Marino A; Skrine Jeffers, Kia; King Robinson, Jan et al. (2018) Contemplative Practices: A Strategy to Improve Health and Reduce Disparities. Int J Environ Res Public Health 15:
Bruce, Marino A; Thorpe Jr, Roland J; Beech, Bettina M et al. (2018) Sex, Race, Food Security, and Sugar Consumption Change Efficacy Among Low-Income Parents in an Urban Primary Care Setting. Fam Community Health 41 Suppl 2 Supp:S25-S32
Bruce, Marino A; Beech, Bettina M; Thorpe Jr, Roland J et al. (2017) Racial and gender disparities in sugar consumption change efficacy among first-year college students. Appetite 109:33-39
Bruce, Marino A; Beech, Bettina M; Norris, Keith C et al. (2017) Sex, Obesity, and Blood Pressure Among African American Adolescents: The Jackson Heart KIDS Pilot Study. Am J Hypertens 30:892-898
Bruce, Marino A; Wilder, Tanganyika; Norris, Keith C et al. (2017) Perspective: Cardiovascular Disease among Young African American Males. Ethn Dis 27:363-366
Bruce, Marino A; Martins, David; Duru, Kenrik et al. (2017) Church attendance, allostatic load and mortality in middle aged adults. PLoS One 12:e0177618
Beech, Bettina M; Bruce, Marino A; Crump, Mary E et al. (2017) The Jackson Heart KIDS Pilot Study: Theory-Informed Recruitment in an African American Population. J Racial Ethn Health Disparities 4:288-296
Kelley, Elizabeth A; Bowie, Janice V; Griffith, Derek M et al. (2016) Geography, Race/Ethnicity, and Obesity Among Men in the United States. Am J Mens Health 10:228-36
Bruce, Marino A; Beech, Bettina M; Griffith, Derek M et al. (2016) Spirituality, Religiosity, and Weight Management Among African American Adolescent Males: The Jackson Heart KIDS Pilot Study. Behav Med 42:183-9
Bruce, Marino A; Beech, Bettina M; Thorpe Jr, Roland J et al. (2016) Racial Disparities in Sugar-Sweetened Beverage Consumption Change Efficacy Among Male First-Year College Students. Am J Mens Health 10:NP168-NP175

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