The prevalence of overweight and obesity is increasing globally, which is thought to account for a substantial number of chronic diseases and cancers. Surgical treatment of obesity has been shown to be effective in long- term weight control, provide additional benefits to people with obesity-related diseases, and reduce relative risk of death. However, it is not universally available to all classes of obese people. The proposed research will closely examine the costs and effectiveness of bariatric surgery. The ultimate goal is to examine the appropriateness of current NIH guidelines and to inform insurance companies, patients, providers, and the government of the most cost-effective surgical treatment of obesity. The Research Specific Aims are to (1) examine the association between obesity, obesity-related comorbidities, and mortality;(2) evaluate the safety and effectiveness of bariatric surgery;(3) investigate the costs attributable to obesity-related diseases;and (4) conduct cost-consequence analyses of bariatric surgery. The research methodology includes econometric modeling (Research Specific Aim 1 and 3), meta-analysis (Research Specific Aim 2), microsimulation (Research Specific Aim 3 and 4), and cost-effectiveness analysis (Research Specific Aim 4). In order to successfully complete the proposed research, this project will also provide the applicant with mentoring by three experts who, in conjunction with didactic training, will enable the applicant to grow into an effective and independent health services research investigator and health economist in obesity prevention and control. The mentoring team and the applicant have worked together and identified three Career Development Aims: (1) to become an independent and externally-funded researcher;(2) to obtain working knowledge of obesity epidemiology and gastroenterology;(3) to enhance the quality of research by obtaining training in the areas of public health and quantitative modeling.
These aims will be achieved through a variety of training strategies, including regular one-on-one meetings with each of three mentors who are experts in the relevant domains, didactic coursework, high-quality online training modules, and attendance at scientific conferences and workshops. The proposed research will provide preliminary data and results for several R21 and an R01 or equivalent applications. These projects will expand to examine other interventions to control obesity, e.g., exercise, diet, medications, and surgery and will be compared within a metric of intensity;alternatively, these projects will examine the relationship between obesity and cancer and how interventions to control obesity can alter this relationship.
This research investigates disease and mortality risks associated with obesity and how surgical treatments of obesity will alter these risks. In addition, costs associated with obesity-attributable comorbidities and surgical treatments will be investigated with the goals of informing the stakeholders of cost-effective surgical treatment and providing evidence to suggest revision of the current National Institutes of Health guidelines regarding the eligibility of weight loss surgery.
|Chang, S-H; Freeman, N L B; Lee, J A et al. (2018) Early major complications after bariatric surgery in the USA, 2003-2014: a systematic review and meta-analysis. Obes Rev 19:529-537|
|Hung, Mei-Chuan; Ekwueme, Donatus U; White, Arica et al. (2018) Estimating health benefits and cost-savings for achieving the Healthy People 2020 objective of reducing invasive colorectal cancer. Prev Med 106:38-44|
|Semenkovich, Tara R; Panni, Roheena Z; Hudson, Jessica L et al. (2018) Comparative effectiveness of upfront esophagectomy versus induction chemoradiation in clinical stage T2N0 esophageal cancer: A decision analysis. J Thorac Cardiovasc Surg 155:2221-2230.e1|
|Chang, Su-Hsin; Yu, Yao-Chi; Carlsson, Nils P et al. (2017) Racial disparity in life expectancies and life years lost associated with multiple obesity-related chronic conditions. Obesity (Silver Spring) 25:950-957|
|Chang, Su-Hsin; Liu, Xiaoyan; Carlsson, Nils P et al. (2017) Reexamining the Association of Body Mass Index With Overall Survival Outcomes After Liver Transplantation. Transplant Direct 3:e172|
|Leung, Man Yee Mallory; Carlsson, Nils P; Colditz, Graham A et al. (2017) The Burden of Obesity on Diabetes in the United States: Medical Expenditure Panel Survey, 2008 to 2012. Value Health 20:77-84|
|Yaghjyan, Lusine; Carlsson, Nils P; Ghita, Gabriela L et al. (2016) Associations of individual characteristics and lifestyle factors with metabolism of di-2-ethylhexyl phthalate in NHANES 2001-2012. Environ Res 149:23-31|
|Yaghjyan, Lusine; Ghita, Gabriela L; Dumont-Driscoll, Marilyn et al. (2016) Maternal exposure to di-2-ethylhexylphthalate and adverse delivery outcomes: A systematic review. Reprod Toxicol 65:76-86|
|Drake, Bettina F; Abadin, Salmafatima S; Lyons, Sarah et al. (2015) Mammograms on-the-go-predictors of repeat visits to mobile mammography vans in St Louis, Missouri, USA: a case-control study. BMJ Open 5:e006960|
|Yaghjyan, L; Sites, S; Ruan, Y et al. (2015) Associations of urinary phthalates with body mass index, waist circumference and serum lipids among females: National Health and Nutrition Examination Survey 1999-2004. Int J Obes (Lond) 39:994-1000|
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