This proposal is for an ADAMHA Research Scientist Development Award - Level I to study the process of emotional regulation in a sample of young children who have experienced severe early life stress. The RSDA would provide me the opportunity to obtain specific research training that is critical for the implementation of the described systematic research program to study serious emotional disturbances in chronically ill children. The specific stressful stimuli that will be studied are severe asthma (an illness characterized by repeated reversible frightening attacks of the inability to breathe) and early multiple hospitalizations. The initial goal is to document specific problems in emotional regulation in young severely asthmatic children (36 to 72 months of age) who have experienced repeated hospitalizations. An experimental paradigm will be used to elicit parent-child interactions that are coded using a sequential scoring system that highlights the affective content of parent and child responses. A severely asthmatic outpatient sample will be studied to examine the effects of severe asthmatic symptoms without the confound of early hospitalization. A sample of children with corrected congenital cardiac abnormalities will also be studied to examine the effects of early hospitalizations without chronic disability or sudden severe respiratory attacks. A third sample of healthy children matched for age, sex, and socioeconomic status will be studied to better understand the processes of early emotional regulation in normal children and to provide a contrast to the clinical samples. Finally, a prospective study is planned to examine the relative effects of genetic, physiologic, allergic, and emotional influences on children at risk for asthma and will investigate the relationship between emotional regulation and prognosis in children who develop the illness.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Scientist Development Award - Research & Training (K01)
Project #
5K01MH000430-03
Application #
3068640
Study Section
Research Scientist Development Review Committee (MHK)
Project Start
1983-07-01
Project End
1988-06-30
Budget Start
1985-07-01
Budget End
1986-06-30
Support Year
3
Fiscal Year
1985
Total Cost
Indirect Cost
Name
National Jewish Health
Department
Type
DUNS #
City
Denver
State
CO
Country
United States
Zip Code
80206
Strunk, R C; Fukuhara, J T; LaBrecque, J F et al. (1989) Outcome of long-term hospitalization for asthma in children. J Allergy Clin Immunol 83:17-25
Gutstadt, L B; Gillette, J W; Mrazek, D A et al. (1989) Determinants of school performance in children with chronic asthma. Am J Dis Child 143:471-5
Strunk, R C; Mrazek, D A; Fukuhara, J T et al. (1989) Cardiovascular fitness in children with asthma correlates with psychologic functioning of the child. Pediatrics 84:460-4
Bender, B G; Belleau, L; Fukuhara, J T et al. (1987) Psychomotor adaptation in children with severe chronic asthma. Pediatrics 79:723-7
Mrazek, D A; Casey, B; Anderson, I (1987) Insecure attachment in severely asthmatic preschool children: is it a risk factor? J Am Acad Child Adolesc Psychiatry 26:516-20
Strunk, R C; Mrazek, D A (1986) Deaths from asthma in childhood: can they be predicted? N Engl Reg Allergy Proc 7:454-61
Strunk, R C; Mrazek, D A; Fuhrmann, G S et al. (1985) Physiologic and psychological characteristics associated with deaths due to asthma in childhood. A case-controlled study. JAMA 254:1193-8