Abstract

The proposed work investigates the relationship between plasma catecholamines and sensory gating of the auditory P50 wave using the evoked potential. Studies have been designed to evaluate the stability of sensory gating in normal subjects, to follow the effects, in normal subjects, on sensory gating of low dose amphetamines, which are psychotomimetic at high doses, and to correlate sensory gating with plasma catecholamines in psychotic patients. As a group they are designed to investigate the possibility that loss of sensory gating is a final common pathway of psychosis which is permanent in schizophrenics, and temporary in other patient populations and in subjects under the influence of psychotomimetic drugs.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Scientist Development Award - Research & Training (K01)
Project #
5K01MH000728-04
Application #
3068803
Study Section
Research Scientist Development Review Committee (MHK)
Project Start
1988-08-01
Project End
1993-06-30
Budget Start
1991-07-01
Budget End
1992-06-30
Support Year
4
Fiscal Year
1991
Total Cost
Indirect Cost

  Institution

Name
University of Colorado Denver
Department
Type
Schools of Medicine
DUNS #
065391526
City
Aurora
State
CO
Country
United States
Zip Code
80045

  Publications

Adler, L E; Olincy, A; Cawthra, E et al. (2001) Reversal of diminished inhibitory sensory gating in cocaine addicts by a nicotinic cholinergic mechanism. Neuropsychopharmacology 24:671-9
Freedman, R; Adler, L E; Nagamoto, H T et al. (1998) Selection of digital filtering parameters and P50 amplitude. Biol Psychiatry 43:921-2
Flach, K A; Adler, L E; Gerhardt, G A et al. (1996) Sensory gating in a computer model of the CA3 neural network of the hippocampus. Biol Psychiatry 40:1230-45
Freedman, R; Hall, M; Adler, L E et al. (1995) Evidence in postmortem brain tissue for decreased numbers of hippocampal nicotinic receptors in schizophrenia. Biol Psychiatry 38:22-33
Griffith, J; Hoffer, L D; Adler, L E et al. (1995) Effects of sound intensity on a midlatency evoked response to repeated auditory stimuli in schizophrenic and normal subjects. Psychophysiology 32:460-6
Waldo, M C; Cawthra, E; Adler, L E et al. (1994) Auditory sensory gating, hippocampal volume, and catecholamine metabolism in schizophrenics and their siblings. Schizophr Res 12:93-106
Adler, L E; Hoffer, L; Nagamoto, H T et al. (1994) Yohimbine impairs P50 auditory sensory gating in normal subjects. Neuropsychopharmacology 10:249-57
Johnson, M R; Adler, L E (1993) Transient impairment in P50 auditory sensory gating induced by a cold-pressor test. Biol Psychiatry 33:380-7
Adler, L E; Hoffer, L D; Wiser, A et al. (1993) Normalization of auditory physiology by cigarette smoking in schizophrenic patients. Am J Psychiatry 150:1856-61
Griffith, J M; Waldo, M; Adler, L E et al. (1993) Normalization of auditory sensory gating in schizophrenic patients after a brief period for sleep. Psychiatry Res 49:29-39

Showing the most recent 10 out of 17 publications