The research project detailed in specific, herein, is a PET study of two major, related neuropsychiatric diseases, OCD and TD. These diseases share features in common not only with each other, but with other neuropsychiatric anxiety, mood, and movement disorders. Regional cerebral glucose metabolism will be studied with fluorodeoxyglucose (FDG), while dopamine and serotonin receptor binding will be measured with fluoro-ethyl-spiperone (FES).
The specific aim i s to determine the neuro-anatomical localization of biochemical abnormalities which underlie the expression of these illnesses. Six groups of subject will be studied with both FDG and FES: 1. OCD without compulsions (""""""""pure obsessionals""""""""), 2. OCD with compulsions, 3. TD without OCD symptoms, 4. TD with OCD symptoms, 5. TD relatives with chronic multiple tic (CMT) and 6. normals. It is hypothesized that subjects with purely mental symptoms (#1) will have orbital gyrus and caudate abnormalities on both FDG and FES-PET, while pure motor symptom patients (#5) will be abnormal only in the putamen. Subject group #3 will have caudate and putamen pathology, while #2 and #4 orbital, caudate and putamen abnormalities and will be indistinguishable from each other. The data collected will be inspected for other findings as well. These studies will further understanding not only of the pathophysiological similarities and differences between OCD and TD (and thus further efforts to control these illnesses), but will also shed light on the neuro-chemical-anatomical organization of higher cerebral function.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Research Scientist Development Award - Research & Training (K01)
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Research Scientist Development Review Committee (MHK)
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University of California Los Angeles
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Martinez, Z A; Colgan, M; Baxter Jr, L R et al. (1997) Oral 18F-fluoro-2-deoxyglucose for primate PET studies without behavioral restraint: demonstration of principle. Am J Primatol 42:215-24
Schwartz, J M; Stoessel, P W; Baxter Jr, L R et al. (1996) Systematic changes in cerebral glucose metabolic rate after successful behavior modification treatment of obsessive-compulsive disorder. Arch Gen Psychiatry 53:109-13
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Baxter Jr, L R (1994) Positron emission tomography studies of cerebral glucose metabolism in obsessive compulsive disorder. J Clin Psychiatry 55 Suppl:54-9
Strouse, T B; Szuba, M P; Baxter Jr, L R (1992) Response to sleep deprivation in three women with postpartum psychosis. J Clin Psychiatry 53:204-6
Szuba, M P; Yager, A; Guze, B H et al. (1992) Disruption of social circadian rhythms in major depression: a preliminary report. Psychiatry Res 42:221-30
Grafton, S T; Mazziotta, J C; Pahl, J J et al. (1992) Serial changes of cerebral glucose metabolism and caudate size in persons at risk for Huntington's disease. Arch Neurol 49:1161-7
Szuba, M P; Altshuler, L L; Baxter Jr, L R (1992) Thyroid function and partial sleep deprivation response. Arch Gen Psychiatry 49:581-2
Baxter Jr, L R; Schwartz, J M; Bergman, K S et al. (1992) Caudate glucose metabolic rate changes with both drug and behavior therapy for obsessive-compulsive disorder. Arch Gen Psychiatry 49:681-9
Baxter Jr, L R (1992) Neuroimaging studies of obsessive compulsive disorder. Psychiatr Clin North Am 15:871-84

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