The long-term career goal of the primary investigator is to advance the knowledge ot schizophrenia-related functional neuropathology by establishing and directing a brain imaging laboratory. The short-term goal is to develop an expertise in the design, execution, and analysis of functional magnetic resonance imaging (fMRI) studies using a series of saccadic tasks. The realization of these goals will occur through a combination of intensive training and the completion of a systematic research plan over the course of the proposed funding period. Training in functional neuroimaging will occur within the UCSD functional neuroimaging group and during yearly 2-week training sessions at the NIMH. Training in neuroanatomy and neuropsychology will be completed within the UCSD neuroscience community. The research plan utilizes the P.I.'s existing studies on the saccadic performance of schizophrenia patients and their relatives as a foundation for generating and testing hypotheses of basal ganglia-thalamocortical circuitry dysfunction associated with schizophrenia. Schizophrenia patients perform normally on refixation saccade tasks, but demonstrate characteristic abnormalities on antisaccade and ocular motor delayed response tasks. A similar pattern of performance is observed among biological relatives of the patients, suggesting that this phenotype may be associated with the liability for developing schizophrenia. The pattern of saccadic performance is consistent with pathology of prefrontal cortex and its associated cortical and/or subcortical circuitry. This hypothesis may be tested using saccadic tasks as behavioral probes during fMRI to measure BOLD (blood oxygenation level dependent) signal change while subjects are engaged in ongoing behavioral and cognitive activity.
Three specific aims are proposed; 1) evaluate the patterns of neural activation associated with refixation saccade performance in schizophrenia and normal subjects, 2) to test hypotheses of differing patterns of frontal activation between schizophrenia and normal groups during tasks that ostensibly require prefrontally-mediated inhibition (antisaccade and delayed response tasks), and 3) to test hypotheses of prefrontal cortex dysfunction among the biological relatives of schizophrenia patients.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Scientist Development Award - Research & Training (K01)
Project #
5K01MH001852-03
Application #
6663650
Study Section
Special Emphasis Panel (ZRG1-BDCN-6 (01))
Program Officer
Wynne, Debra K
Project Start
2001-08-10
Project End
2006-07-31
Budget Start
2003-08-01
Budget End
2004-07-31
Support Year
3
Fiscal Year
2003
Total Cost
$117,213
Indirect Cost
Name
University of Georgia
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
004315578
City
Athens
State
GA
Country
United States
Zip Code
30602
Schaeffer, David J; Amlung, Michael T; Li, Qingyang et al. (2013) Neural correlates of behavioral variation in healthy adults' antisaccade performance. Psychophysiology 50:325-33
Lee, Jinae; Park, Cheolwoo; Dyckman, Kara A et al. (2013) Practice-related changes in neural activation patterns investigated via wavelet-based clustering analysis. Hum Brain Mapp 34:2276-91
McDowell, Jennifer E; Dyckman, Kara A; Austin, Benjamin P et al. (2008) Neurophysiology and neuroanatomy of reflexive and volitional saccades: evidence from studies of humans. Brain Cogn 68:255-70
Camchong, Jazmin; Dyckman, Kara A; Austin, Benjamin P et al. (2008) Common neural circuitry supporting volitional saccades and its disruption in schizophrenia patients and relatives. Biol Psychiatry 64:1042-50
Clementz, Brett A; Brahmbhatt, Shefali B; McDowell, Jennifer E et al. (2007) When does the brain inform the eyes whether and where to move? An EEG study in humans. Cereb Cortex 17:2634-43
Dyckman, Kara A; Camchong, Jazmin; Clementz, Brett A et al. (2007) An effect of context on saccade-related behavior and brain activity. Neuroimage 36:774-84
Gutherie, Audrey H; McDowell, Jennifer E; Hammond Jr, Billy R (2006) Scotopic sensitivity in schizophrenia. Schizophr Res 84:378-85
McDowell, Jennifer E; Brown, Gregory G; Lazar, Nicole et al. (2006) The neural correlates of habituation of response to startling tactile stimuli presented in a functional magnetic resonance imaging environment. Psychiatry Res 148:1-10
Dyckman, Kara A; McDowell, Jennifer E (2005) Behavioral plasticity of antisaccade performance following daily practice. Exp Brain Res 162:63-9
McDowell, Jennifer E; Kissler, Johanna M; Berg, Patrick et al. (2005) Electroencephalography/magnetoencephalography study of cortical activities preceding prosaccades and antisaccades. Neuroreport 16:663-8