This resubmission of an application (K01 MH01857-01) for an MRSDA outlines a program of training and research in the cognitive neuroscience of emotion in healthy and: anxiety-disordered subjects. The candidate is a new Assistant Professor with previous training in clinical-cognitive neuroscience. His recent work has focused on working memory and prefrontal cortex functioning in severe psychopathology. This proposal seeks to build on this work and develop the candidate's research skills in the areas of affective information processing, autonomic and somatic psychophysiology, and hemodynamic and electroencenphalographic human brain imaging methods. The candidate will be mentored in the design and conduct of a set of related studies using standardized affective stimuli in a cognitive task that simultaneously engages prefrontal cortex and functionally-connected emotion-critical brain regions. The overall purpose of this research is to develop a new experimental approach-based on psychophysiological recording of bodily activity, and complementary measures of brain activity-to study the interaction between high-level cortex and deeper brain structures that mediate normal and abnormal emotional experience and its physiological expression. To achieve these goals, the candidate will pursue career development activities which build upon his existing skills and enhance his expertise in: (a) The design, conduct, and analysis of high-density electroencephalographic and functional MRI studies; (b) developing conceptual and practical skills to integrate these brain imaging methods; (c) developing skills necessary for assessment and empirical measurement of anxiety disorder symptomatology; and (d) extending a knowledge base of functional neuroanatomy and circuitry based on animal models to inform this research approach. The following specific aims are addressed: (a) Develop a probe of prefrontal cortical and emotion-critical deep cortical and subcortical structures; (b) employ imaging methods to track probe effects on affect-working memory interactions in the brain; and (c) apply probe and imaging methods to clinically fear-disordered patients to test hypotheses concerning regional brain interactions and their dysfunction. The preceptor, Dr. Peter Lang, will provide mentorship in cooperation with expert consultants to ensure a coherent and intellectually rigorous framework for career development and research conduct. This training, which can not be accomplished under any other funding mechanism, will enable the candidate to combine, in the most informative ways possible, clinical and cognitive psychology, electrocortical and hemodynamic measures of brain activity, and anxiety disorder symptom assessment. Completion of this award would place the candidate in the position to continue programmatic research along these lines and provide a unique contribution to the cognitive neuroscience study of emotion and its disorders.
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| Larson, Michael J; Fair, Joseph E; Farrer, Thomas J et al. (2011) Predictors of performance monitoring abilities following traumatic brain injury: the influence of negative affect and cognitive sequelae. Int J Psychophysiol 82:61-8 |
| Demery, Jason A; Larson, Michael J; Dixit, Neha K et al. (2010) Operating characteristics of executive functioning tests following traumatic brain injury. Clin Neuropsychol 24:1292-308 |
| Larson, Michael J; Kaufman, David A S; Perlstein, William M (2009) Neural time course of conflict adaptation effects on the Stroop task. Neuropsychologia 47:663-70 |
| Larson, Michael J; Perlstein, William M (2009) Awareness of deficits and error processing after traumatic brain injury. Neuroreport 20:1486-90 |
| Larson, Michael J; Kaufman, David A S; Perlstein, William M (2009) Conflict adaptation and cognitive control adjustments following traumatic brain injury. J Int Neuropsychol Soc 15:927-37 |
| Larson, Michael J; Kaufman, David A S; Kellison, Ida L et al. (2009) Double jeopardy! The additive consequences of negative affect on performance-monitoring decrements following traumatic brain injury. Neuropsychology 23:433-44 |
| Larson, Michael J; Kaufman, David A S; Schmalfuss, Ilona M et al. (2007) Performance monitoring, error processing, and evaluative control following severe TBI. J Int Neuropsychol Soc 13:961-71 |
| Larson, Michael J; Kelly, Kiesa G; Stigge-Kaufman, David A et al. (2007) Reward context sensitivity impairment following severe TBI: an event-related potential investigation. J Int Neuropsychol Soc 13:615-25 |
| Larson, Michael J; Perlstein, William M; Demery, Jason A et al. (2006) Cognitive control impairments in traumatic brain injury. J Clin Exp Neuropsychol 28:968-86 |
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