This is a request for an NIMH Scientist Development Award (K01) to provide training and research experience in a broad range of approaches aimed at studying pediatric bipolar disorder. The candidate's goal is to foster his development as an independent investigator and to apply the knowledge acquired during this training to ongoing research. The candidate is proposing a comprehensive, systematic, portfolio of research designed to examine the validity and heterogeneity of pediatric bipolar disorder using data from several large existing cross-sectional and longitudinal clinical research databases. The studies that created these data sets have comprehensively assessed youth, and their first degree relatives on multiple, nonoverlapping domains of functioning. The overarching aim of the proposed research is to determine whether pediatric onset bipolar disorder is a valid entity and if so, what are the core features of the disorder and its boundaries from other disorders.
This aim will be carried out with psychometric analyses that will identify the particular symptoms of bipolar disorder that are most efficient in making the diagnosis in children. Latent class analyses will be conducted to identify subforms of bipolar disorder based upon symptom course and expression that are not biased by diagnostic preconceptions. Once defined, the validity of these subtypes will be tested in examinations of their clinical correlates, course and stability, familiality, and differentiation from attention-deficit hyperactivity disorder. To further characterize the putative subtypes of bipolar disorder, the candidate will conduct path analyses of the onset of psychiatric comorbidity in order to identify different trajectories that may lead to the disorder in children. Consistent with research of the etiology of other childhood psychopathology, the candidate proposes to study the family environment, the climate surrounding early development, the in utero environment, and individual behavioral traits as potential risk factors for pediatric bipolar disorder. The candidate has selected mentors and consultants who will provide him with the opportunity to augment the skills obtained during his training in epidemiology with new statistical and data analytic methods needed to carry out the specific aims of the proposed research. This systematic approach of research and training may lead to advances in early intervention and prevention of pediatric bipolar disorder.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Scientist Development Award - Research & Training (K01)
Project #
5K01MH065523-05
Application #
7145552
Study Section
Biobehavioral and Behavioral Processes 3 (BBBP)
Program Officer
Avenevoli, Shelli A
Project Start
2002-12-01
Project End
2008-11-30
Budget Start
2006-12-01
Budget End
2008-11-30
Support Year
5
Fiscal Year
2007
Total Cost
$177,421
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02199
Wozniak, J; Faraone, S V; Mick, E et al. (2010) A controlled family study of children with DSM-IV bipolar-I disorder and psychiatric co-morbidity. Psychol Med 40:1079-88
Mick, Eric; Faraone, Stephen V (2009) Family and genetic association studies of bipolar disorder in children. Child Adolesc Psychiatr Clin N Am 18:441-53, x
Mick, Eric; Wozniak, Janet; Wilens, Timothy E et al. (2009) Family-based association study of the BDNF, COMT and serotonin transporter genes and DSM-IV bipolar-I disorder in children. BMC Psychiatry 9:2
Henin, Aude; Mick, Eric; Biederman, Joseph et al. (2009) Is psychopharmacologic treatment associated with neuropsychological deficits in bipolar youth? J Clin Psychiatry 70:1178-85
Mick, Eric; Kim, Jang Woo; Biederman, Joseph et al. (2008) Family based association study of pediatric bipolar disorder and the dopamine transporter gene (SLC6A3). Am J Med Genet B Neuropsychiatr Genet 147B:1182-5
Mick, Eric; Faraone, Stephen V; Spencer, Thomas et al. (2008) Assessing the validity of the Quality of Life Enjoyment and Satisfaction Questionnaire Short Form in adults with ADHD. J Atten Disord 11:504-9
Biederman, Joseph; Mick, Eric O; Surman, Craig et al. (2007) Comparative acute efficacy and tolerability of OROS and immediate release formulations of methylphenidate in the treatment of adults with attention-deficit/hyperactivity disorder. BMC Psychiatry 7:49
Harpold, Theresa; Biederman, Joseph; Gignac, Martin et al. (2007) Is oppositional defiant disorder a meaningful diagnosis in adults? Results from a large sample of adults with ADHD. J Nerv Ment Dis 195:601-5
Mick, Eric; Biederman, Joseph; Spencer, Thomas et al. (2006) Absence of association with DAT1 polymorphism and response to methylphenidate in a sample of adults with ADHD. Am J Med Genet B Neuropsychiatr Genet 141B:890-4
Mick, Eric; Spencer, Thomas; Wozniak, Janet et al. (2005) Heterogeneity of irritability in attention-deficit/hyperactivity disorder subjects with and without mood disorders. Biol Psychiatry 58:576-82

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