(provided by candidate): This is a revised application for a Mentored Research Scientist Development Award (K01). The candidate is a social psychologist who proposes to acquire the knowledge and skills to design and implement psychosocial interventions for family caregivers to clinically-depressed older adults. Depression in late life is associated with increased health care utilization, amplification of physical disability, cognitive impairment, and increased risk for suicide. Although remission of late-life depression can be achieved with pharmacotherapy and psychotherapy, the long-term prognosis for patients is mixed. Family members who provide support and physical assistance to depressed older patients are at high risk for psychiatric and physical morbidity of their own, and may play a critical role in patient treatment adherence and response. The candidate's proposed career development activities focus on acquiring knowledge of the pharmacologic and psychotherapeutic treatment of late-life depression, as a platform for additional training and research activities focused on the assessment and psychosocial treatment of family caregivers to late-life depression patients. In addition, the candidate aims to master advanced statistical techniques for analyzing treatment outcomes for older depressed patients and their family caregivers. The Research Plan of this application includes a study that will examine the prospective relationships between caregiver factors (knowledge, attitudes, burden, and psychiatric symptomatology) and patient treatment adherence and response. A second study will evaluate a pilot psychosocial treatment for adult children of older adults receiving psychiatric treatment for major depression that is designed to provide these caregivers with information and support. Treatment benefits experienced by caregivers may extend to older patients by increasing the likelihood that they will recover from depression and stay well.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Scientist Development Award - Research & Training (K01)
Project #
5K01MH065547-04
Application #
6992714
Study Section
Special Emphasis Panel (ZMH1-ITV-D (01))
Program Officer
Wynne, Debra K
Project Start
2002-12-18
Project End
2007-11-30
Budget Start
2005-12-01
Budget End
2006-11-30
Support Year
4
Fiscal Year
2006
Total Cost
$128,616
Indirect Cost
Name
University of Pittsburgh
Department
Psychiatry
Type
Schools of Medicine
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Polenick, Courtney Allyn; Martire, Lynn M (2013) Caregiver attributions for late-life depression and their associations with caregiver burden. Fam Process 52:709-22
Reynolds 3rd, Charles F; Dew, Mary Amanda; Martire, Lynn M et al. (2010) Treating depression to remission in older adults: a controlled evaluation of combined escitalopram with interpersonal psychotherapy versus escitalopram with depression care management. Int J Geriatr Psychiatry 25:1134-41
Martire, Lynn M; Schulz, Richard; Reynolds 3rd, Charles F et al. (2010) Treatment of late-life depression alleviates caregiver burden. J Am Geriatr Soc 58:23-9
Monin, Joan K; Martire, Lynn M; Schulz, Richard et al. (2009) Willingness to express emotions to caregiving spouses. Emotion 9:101-6
Martire, Lynn M; Hinrichsen, Gregory A; Morse, Jennifer Q et al. (2009) The Mood Disorder Burden Index: a scale for assessing the burden of caregivers to adults with unipolar or bipolar disorder. Psychiatry Res 168:67-77
Martire, Lynn M; Schulz, Richard; Keefe, Francis J et al. (2008) Couple-Oriented Education and Support Intervention for Osteoarthritis: Effects on Spouses'Support and Responses to Patient Pain. Fam Syst Health 26:185-195
Martire, Lynn M; Schulz, Richard; Reynolds, Charles F et al. (2008) Impact of close family members on older adults'early response to depression treatment. Psychol Aging 23:447-52
Martire, Lynn M; Keefe, Francis J; Schulz, Richard et al. (2006) Older spouses' perceptions of partners' chronic arthritis pain: implications for spousal responses, support provision, and caregiving experiences. Psychol Aging 21:222-30
Hebert, R S; Weinstein, E; Martire, L M et al. (2006) Religion, spirituality and the well-being of informal caregivers: a review, critique, and research prospectus. Aging Ment Health 10:497-520
Schulz, Richard; Martire, Lynn M; Klinger, Julie N (2005) Evidence-based caregiver interventions in geriatric psychiatry. Psychiatr Clin North Am 28:1007-38, x

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