The proposed research is in response to PA-00-019, Mentored Research Scientist Development Award (K01). The candidate is an Assistant Research Professor in the Department of Psychiatry at Duke University. Duke University has a well-established research program in the areas of psychiatric epidemiology and multi-dimensional aspects of aging. The candidate has a strong background in survey research and holds graduate degrees in epidemiology. Her immediate career goals are to further increase her substantive expertise in aging, geriatric psychiatry, and psychiatric epidemiology with a continued focus on depression in late life, develop her quantitative skills through the use of advanced statistical models for the analysis of longitudinal data, and become more proficient in the publication process. Long-term career goals include the conduct of investigator-initiated research within the environment of an academic research center. The proposed plan will include time for independent study, attendance at seminars, conducting data analysis and ? learning new statistical techniques, manuscript preparation, and developing independent R01 applications near the completion of the award. The proposed research project will be undertaken to explore the interrelationship of depression and physical functioning in a community sample of older adults over time. Specifically, the aims will be 1) to develop an explanatory model of this interrelationship; 2) to compare the trajectories of depression and physical functioning over a ten-year follow-up period; and 3) to identify demographic and social factors as well as indicators of physical health status that affect these trajectories overtime. Data from the Duke Established Populations of Epidemiologic Studies of the Elderly (EPESE) will be used to develop the model and address the dynamics of the depression and functioning relationship. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Scientist Development Award - Research & Training (K01)
Project #
5K01MH066380-02
Application #
6704742
Study Section
Social Sciences, Nursing, Epidemiology and Methods 4 (SNEM)
Program Officer
Mayo, Donna J
Project Start
2003-04-01
Project End
2008-01-31
Budget Start
2004-02-01
Budget End
2005-01-31
Support Year
2
Fiscal Year
2004
Total Cost
$104,355
Indirect Cost
Name
Duke University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Sachs-Ericsson, Natalie; Hames, Jennifer L; Joiner, Thomas E et al. (2014) Differences between suicide attempters and nonattempters in depressed older patients: depression severity, white-matter lesions, and cognitive functioning. Am J Geriatr Psychiatry 22:75-85
Sachs-Ericsson, Natalie; Corsentino, Elizabeth; Moxley, Jerad et al. (2013) A longitudinal study of differences in late- and early-onset geriatric depression: depressive symptoms and psychosocial, cognitive, and neurological functioning. Aging Ment Health 17:1-11
Rushing, Nicole C; Corsentino, Elizabeth; Hames, Jennifer L et al. (2013) The relationship of religious involvement indicators and social support to current and past suicidality among depressed older adults. Aging Ment Health 17:366-74
Sawyer, Kathryn; Corsentino, Elizabeth; Sachs-Ericsson, Natalie et al. (2012) Depression, hippocampal volume changes, and cognitive decline in a clinical sample of older depressed outpatients and non-depressed controls. Aging Ment Health 16:753-62
Sachs-Ericsson, Natalie; Selby, Edward; Corsentino, Elizabeth et al. (2012) Depressed older patients with the atypical features of interpersonal rejection sensitivity and reversed-vegetative symptoms are similar to younger atypical patients. Am J Geriatr Psychiatry 20:622-34
Oddone, Cameron G; Hybels, Celia F; McQuoid, Douglas R et al. (2011) Social support modifies the relationship between personality and depressive symptoms in older adults. Am J Geriatr Psychiatry 19:123-31
Hybels, Celia F; Blazer, Dan G; Landerman, Lawrence R et al. (2011) Heterogeneity in symptom profiles among older adults diagnosed with major depression. Int Psychogeriatr 23:906-22
Dickinson, Whitney J; Potter, Guy G; Hybels, Celia F et al. (2011) Change in stress and social support as predictors of cognitive decline in older adults with and without depression. Int J Geriatr Psychiatry 26:1267-74
Sachs-Erisson, Natalie; Sawyer, Kathryn; Corsentino, Elizabeth et al. (2011) The moderating effect of the APOE [small element of] 4 allele on the relationship between hippocampal volume and cognitive decline in older depressed patients. Am J Geriatr Psychiatry 19:23-32
Hybels, Celia F; Pieper, Carl F; Blazer, Dan G et al. (2010) Trajectories of mobility and IADL function in older patients diagnosed with major depression. Int J Geriatr Psychiatry 25:74-81

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