Perinatal depression has serious adverse effects, including harming the nutritional status of mothers and children. Depressive symptoms may also be affected by poor nutrition. The goal of this proposal is to provide Dr. Lisa Bodnar with the mental health training she needs to become an independent investigator and nutritional interventionist in perinatal mental health. Dr. Bodnar is a nutritional epidemiologist in the area of perinatology. Her interest in nutritional aspects of perinatal psychiatry represents a natural extension of her previous work. Her short-term goals are: (1) to acquire a clear understanding of neurobiology, psychiatry, and methodological approaches used to assess mental health outcomes;(2) to gain practical experience in the diagnosis and evaluation of treatment response of mood disorders in women;and (3) to obtain pilot data to inform a methodologically rigorous protocol for an R01 grant application to conduct a large prospective study of the nutritional contributors to and consequences of perinatal mood disorders. She will achieve these goals through a training plan that incorporates mentoring, coursework, a clinical practicum, seminars, directed readings, manuscript writing, and training in the responsible conduct of research. The institutional support of the epidemiology and psychiatry departments at the University of Pittsburgh will foster her ability to develop the skills necessary to successfully compete for research funding. The project to support these goals will use data from a naturalistic, longitudinal study (R01 MH60335;KL Wisner, PI) of the consequences of depression and antidepressant use during pregnancy to: (1) characterize the perinatal nutritional status of women with depression women treated with antidepressants for depression, and their offspring, (2) gain a greater understanding of the interaction of nutritional status and body weight during pregnancy and postpartum on depressive symptoms;and (3) elucidate the role of nutrition in the pathophysiology of depression.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Research Scientist Development Award - Research & Training (K01)
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Adult Psychopathology and Disorders of Aging Study Section (APDA)
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Avenevoli, Shelli A
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University of Pittsburgh
Public Health & Prev Medicine
Schools of Public Health
United States
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Tomedi, Laura E; Chang, Chung-Chou H; Newby, P K et al. (2013) Pre-pregnancy obesity and maternal nutritional biomarker status during pregnancy: a factor analysis. Public Health Nutr 16:1414-8
Tomedi, Laura Elizabeth; Bogen, Debra L; Hanusa, Barbara H et al. (2012) A pilot study of the nutritional status of opiate-using pregnant women on methadone maintenance therapy. Subst Use Misuse 47:286-95
Bodnar, Lisa M; Wisner, Katherine L; Luther, James F et al. (2012) An exploratory factor analysis of nutritional biomarkers associated with major depression in pregnancy. Public Health Nutr 15:1078-86
Simhan, Hyagriv N; Himes, Katherine P; Venkataramanan, Raman et al. (2011) Maternal serum folate species in early pregnancy and lower genital tract inflammatory milieu. Am J Obstet Gynecol 205:61.e1-7
McClure, Candace K; Bodnar, Lisa M; Ness, Roberta et al. (2011) Accuracy of maternal recall of gestational weight gain 4 to 12 years after delivery. Obesity (Silver Spring) 19:1047-53
Miljkovic, Iva; Bodnar, Lisa M; Cauley, Jane A et al. (2011) Low prevalence of vitamin D deficiency in elderly Afro-Caribbean men. Ethn Dis 21:79-84
Bodnar, Lisa M; Hutcheon, Jennifer A; Platt, Robert W et al. (2011) Should gestational weight gain recommendations be tailored by maternal characteristics? Am J Epidemiol 174:136-46
Bodnar, Lisa M; Simhan, Hyagriv N (2010) Vitamin D may be a link to black-white disparities in adverse birth outcomes. Obstet Gynecol Surv 65:273-84
Bodnar, Lisa M; Siega-Riz, Anna Maria; Simhan, Hyagriv N et al. (2010) The impact of exposure misclassification on associations between prepregnancy BMI and adverse pregnancy outcomes. Obesity (Silver Spring) 18:2184-90
Bodnar, Lisa M; Catov, Janet M; Zmuda, Joseph M et al. (2010) Maternal serum 25-hydroxyvitamin D concentrations are associated with small-for-gestational age births in white women. J Nutr 140:999-1006

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