The proposed Mentored Research Scientist Development Award (K01) is a 5-year plan for Rachel Marsh, Ph.D. to develop into an independent investigator of the neural systems that mediate self-regulatory control processes and habit learning in childhood psychopathologies. Advancing our understanding of abnormalities in these systems may shed light on the pathophysiology and pathogenesis of disorders in which children and adolescents are plagued by the presence of impulsive and habitual behaviors. This application requests support for a career development and research plan to study self-regulatory control processes and habit learning in adolescents with Bulimia Nervosa (BN). The career development activities build on Dr. Marsh's background in developmental and experimental psychology and capitalize on the resources at Columbia University to allow her to achieve her long-term goal of becoming an independent investigator of childhood psychopathologies. These activities integrate both formal didactic experience and hands-on practicum that will enable her to: (1) develop expertise in functional neuroimaging techniques; (2) acquire more comprehensive knowledge of basic and cognitive neuroscience; (3) increase her understanding of the clinical phenotypes and pathophysiology of childhood disorders; and (4) gain clinical experience in the assessment of BN and expertise in its pathophysiology. Complementing these training activities, Dr. Marsh proposes to use fMRI to identify functional impairments of frontostriatal circuitry, the primary mediator of self- regulatory control, in adolescents with BN that may predict the presence or perpetuation of the disorder. The proposed research will also help to define the functional characteristics of habit-learning systems within the basal ganglia that may be abnormal in adolescents with BN and contribute to their habitual binging and purging behaviors. Disturbances in frontstriatal systems may release the underlying vulnerabilities to develop BN from regulatory control, contributing to the expression of these habitual behaviors. Findings from this study will have wide-ranging importance for the understanding of the development and treatment of BN and help to define the role of self-regulatory control and habit-learning systems in other pathological conditions that originate in childhood. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Scientist Development Award - Research & Training (K01)
Project #
5K01MH077652-03
Application #
7485842
Study Section
Child Psychopathology and Developmental Disabilities Study Section (CPDD)
Program Officer
Garvey, Marjorie A
Project Start
2006-08-17
Project End
2011-07-31
Budget Start
2008-08-01
Budget End
2009-07-31
Support Year
3
Fiscal Year
2008
Total Cost
$175,998
Indirect Cost
Name
Columbia University (N.Y.)
Department
Psychiatry
Type
Schools of Medicine
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
Berner, Laura A; Stefan, Mihaela; Lee, Seonjoo et al. (2018) Altered cortical thickness and attentional deficits in adolescent girls and women with bulimia nervosa. J Psychiatry Neurosci 43:151-160
Labouliere, Christa D; Terranova, Kate; Steinglass, Joanna et al. (2016) Implicit learning on a probabilistic classification task in adults and adolescents with Bulimia Nervosa. J Psychiatr Res 77:35-41
He, Xiaofu; Stefan, Mihaela; Terranova, Kate et al. (2016) Altered White Matter Microstructure in Adolescents and Adults with Bulimia Nervosa. Neuropsychopharmacology 41:1841-8
Marsh, Rachel; Tau, Gregory Z; Wang, Zhishun et al. (2015) Reward-based spatial learning in unmedicated adults with obsessive-compulsive disorder. Am J Psychiatry 172:383-92
Marsh, Rachel; Stefan, Mihaela; Bansal, Ravi et al. (2015) Anatomical characteristics of the cerebral surface in bulimia nervosa. Biol Psychiatry 77:616-23
Horga, Guillermo; Maia, Tiago V; Marsh, Rachel et al. (2015) Changes in corticostriatal connectivity during reinforcement learning in humans. Hum Brain Mapp 36:793-803
Horga, Guillermo; Kaur, Tejal; Peterson, Bradley S (2014) Annual research review: Current limitations and future directions in MRI studies of child- and adult-onset developmental psychopathologies. J Child Psychol Psychiatry 55:659-80
Marsh, Rachel; Horga, Guillermo; Parashar, Nidhi et al. (2014) Altered activation in fronto-striatal circuits during sequential processing of conflict in unmedicated adults with obsessive-compulsive disorder. Biol Psychiatry 75:615-22
Berner, Laura A; Marsh, Rachel (2014) Frontostriatal circuits and the development of bulimia nervosa. Front Behav Neurosci 8:395
Marsh, Rachel; Horga, Guillermo; Wang, Zhishun et al. (2011) An FMRI study of self-regulatory control and conflict resolution in adolescents with bulimia nervosa. Am J Psychiatry 168:1210-20

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