Through the training outlined in this Mentored Career Development Application, the candidate will advance her understanding of developmental processes and work toward her goal of becoming a developmental psychopathologist. The candidate will receive developmentally-focused training on psychopathology, psychobiology and adolescent development in order to become an independent interdisciplinary researcher capable of answering questions about the role of early experience in shaping the emergence of psychopathology in adolescents at risk. The candidate will be more prepared at the end of 5 years to embark on independent research. This study examines the role of Early and Concurrent stress exposure in shaping the development of stress regulation and risk for psychopathology in adolescents. This study investigates early stress exposure in maltreated and internationally adopted post-institutionalized children to explore whether early Stress Alone or in combination with Concurrent Stress is necessary to result in endocrine dysregulation. This study is unique because it uses multiple hormones measured across different ecologically-valid social contexts in order to characterize stress regulation. Early Stress Alone is hypothesized to be capable of altering stress regulation and psychopathology risk in adolescents as compared to high socioeconomic status youth. Adolescents who have experienced Early and Concurrent Stress will be compared to adolescents of similar socioeconomic strata to aid interpretation of the Early Stress Alone effects. Stress regulation is characterized as normal diurnal rhythms in the first phase of the study. Phase II, two years later, is designed to rigorously assess the ability of novelty and social salience to influence hormonal activation and recovery from three laboratory based tests. A prospective, longitudinal extension across Phase I and II will allow us to evaluate these adolescents'risk for mental health symptoms and disorders. Psychopathology symptoms expressed in early adolescents are hypothesized to emerge as mental health disorders in a subset of participants two years later. These disorders will be most likely in those who show evidence of stress dysregulation.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Research Scientist Development Award - Research & Training (K01)
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Study Section
Biobehavioral Mechanisms of Emotion, Stress and Health Study Section (MESH)
Program Officer
Sarampote, Christopher S
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Louisiana State University-University of New Orleans
Schools of Arts and Sciences
New Orleans
United States
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Shirtcliff, Elizabeth A; Skinner, Martie L; Obasi, Ezemenari M et al. (2017) Positive parenting predicts cortisol functioning six years later in young adults. Dev Sci 20:
Phan, Jenny M; Schneider, Ekaterina; Peres, Jeremy et al. (2017) Social evaluative threat with verbal performance feedback alters neuroendocrine response to stress. Horm Behav 96:104-115
Dismukes, Andrew R; Shirtcliff, Elizabeth A; Hanson, Jamie L et al. (2015) Context influences the interplay of endocrine axes across the day. Dev Psychobiol 57:731-41
Hanson, Jamie L; Nacewicz, Brendon M; Sutterer, Matthew J et al. (2015) Behavioral problems after early life stress: contributions of the hippocampus and amygdala. Biol Psychiatry 77:314-23
Van Hulle, Carol A; Moore, Mollie N; Shirtcliff, Elizabeth A et al. (2015) Genetic and Environmental Contributions to Covariation Between DHEA and Testosterone in Adolescent Twins. Behav Genet 45:324-40
Ruttle, Paula L; Shirtcliff, Elizabeth A; Armstrong, Jeffrey M et al. (2015) Neuroendocrine coupling across adolescence and the longitudinal influence of early life stress. Dev Psychobiol 57:688-704
Gostisha, Andrew J; Vitacco, Michael J; Dismukes, Andrew R et al. (2014) Beyond physiological hypoarousal: the role of life stress and callous-unemotional traits in incarcerated adolescent males. Horm Behav 65:469-79
Theall, Katherine P; Brett, Zoe H; Shirtcliff, Elizabeth A et al. (2013) Neighborhood disorder and telomeres: connecting children's exposure to community level stress and cellular response. Soc Sci Med 85:50-8
Shirtcliff, Elizabeth A; Phan, Jenny M; Lubach, Gabriele R et al. (2013) Stability of parental care across siblings from undisturbed and challenged pregnancies: intrinsic maternal dispositions of female rhesus monkeys. Dev Psychol 49:2005-16
Loevinger, Barbara L; Shirtcliff, Elizabeth A; Muller, Daniel et al. (2012) Delineating psychological and biomedical profiles in a heterogeneous fibromyalgia population using cluster analysis. Clin Rheumatol 31:677-85

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