The aim of this Mentored Research Scientist Development Award (K01) is to provide the applicant with the skills and knowledge necessary to develop and test exercise interventions to promote symptom management and quality of life in cancer patients receiving intensive therapy. Specific career objectives are to: 1) study exercise physiology to develop and test exercise interventions that can be implemented in cancer patients receiving intensive therapy, 2) study health promotion theories, such as self-efficacy theory, as a means to enhance exercise adherence in cancer patients, and 3) gain knowledge and research skills in randomized clinical trial methodology. A two-phase research study is proposed. In phase I of the study, the exercise intervention will be implemented in a small group of autologous stem cell transplant patients (n=5). The intervention will be pilot tested to determine acceptability and feasibility with respect to the appropriate time for initiating the intervention and intensity of exercise intervention. The strength training intervention will be refined as needed. In Phase II of the study, a 2-group, randomized controlled study (n=20) will be conducted to test the effects of the strength training intervention on the primary outcomes: a) physical activity, and b) muscle strength; and secondary outcomes a) fatigue, b) health status perceptions, and c) quality of life. It is hypothesized that autologous stem cell transplant patients receiving strength training will demonstrate significant improvements in physical activity, muscle strength, fatigue, health status perceptions, and quality of life as compared to autologous stem cell transplant patients who do not receive any type of training. This research will yield valuable information regarding effective interventions aimed at mitigating problems, such as physical inactivity, loss of strength, and fatigue. This information will also be used to increase the likelihood of long-term successful outcomes, such as the ability to maintain or return to productive roles in society and improvement of quality of life in cancer patients receiving intensive therapy.

Agency
National Institute of Health (NIH)
Institute
National Institute of Nursing Research (NINR)
Type
Research Scientist Development Award - Research & Training (K01)
Project #
5K01NR009375-02
Application #
7065721
Study Section
National Institute of Nursing Research Initial Review Group (NRRC)
Program Officer
Hare, Martha L
Project Start
2005-05-16
Project End
2008-04-30
Budget Start
2006-05-01
Budget End
2007-04-30
Support Year
2
Fiscal Year
2006
Total Cost
$90,934
Indirect Cost
Name
University of Illinois at Chicago
Department
Other Health Professions
Type
Schools of Nursing
DUNS #
098987217
City
Chicago
State
IL
Country
United States
Zip Code
60612
Ryan, Catherine J; Choi, Heeseung; Fritschi, Cynthia et al. (2013) Challenges and solutions for using informatics in research. West J Nurs Res 35:722-41
Hacker, Eileen Danaher; Larson, Janet; Kujath, Amber et al. (2011) Strength training following hematopoietic stem cell transplantation. Cancer Nurs 34:238-49
Hacker, Eileen Danaher; Larson, Janet L; Peace, David (2011) Exercise in patients receiving hematopoietic stem cell transplantation: lessons learned and results from a feasibility study. Oncol Nurs Forum 38:216-23
Hacker, Eileen Danaher (2010) Technology and quality of life outcomes. Semin Oncol Nurs 26:47-58
Hacker, Eileen (2009) Exercise and quality of life: strengthening the connections. Clin J Oncol Nurs 13:31-9