Function of GFL-Dependent &Independent RET Activation

Pierchala, Brian Anthony

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Neurological Disorders and Stroke (NINDS)
• Type: Research Scientist Development Award - Research & Training (K01)
• Project #: 5K01NS045221-02
• Application #: 6685982
• Study Section: Molecular, Cellular and Developmental Neurosciences 2 (MDCN)
• Program Officer: Mamounas, Laura
• Project Start: 2002-12-15
• Project End: 2007-11-30
• Budget Start: 2003-12-01
• Budget End: 2004-11-30
• Support Year: 2
• Fiscal Year: 2004
• Total Cost: $114,091

Institution

• Name: Washington University
• Department: Anatomy/Cell Biology
• Type: Schools of Medicine
• DUNS #: 068552207
• City: Saint Louis
• State: MO
• Country: United States
• Zip Code: 63130

Publications

Tsui, Cynthia C; Pierchala, Brian A (2010) The differential axonal degradation of Ret accounts for cell-type-specific function of glial cell line-derived neurotrophic factor as a retrograde survival factor. J Neurosci 30:5149-58

Tsui, Cynthia C; Pierchala, Brian A (2008) CD2AP and Cbl-3/Cbl-c constitute a critical checkpoint in the regulation of ret signal transduction. J Neurosci 28:8789-800

Pierchala, Brian A; Tsui, Cynthia C; Milbrandt, Jeffrey et al. (2007) NGF augments the autophosphorylation of Ret via inhibition of ubiquitin-dependent degradation. J Neurochem 100:1169-76

Pierchala, Brian A; Milbrandt, Jeffrey; Johnson Jr, Eugene M (2006) Glial cell line-derived neurotrophic factor-dependent recruitment of Ret into lipid rafts enhances signaling by partitioning Ret from proteasome-dependent degradation. J Neurosci 26:2777-87

Pierchala, Brian A; Ahrens, Rebecca C; Paden, Andrew J et al. (2004) Nerve growth factor promotes the survival of sympathetic neurons through the cooperative function of the protein kinase C and phosphatidylinositol 3-kinase pathways. J Biol Chem 279:27986-93