The objective of the proposal outlined is to provide a 5-yr research and career development program for Deborah A. Russell, D.V.M., M.S. under the sponsorship of Gilbert A. Castro, Ph. D., Professor, Department of Physiology and Cell Biology, University of Texas Medical School at Houston. Dennis Kohn, D.V.M., Ph. D., Chairman, Department of Comparative Medicine will serve as co-sponsor. The candidate will have an academic appointment in the Dept. of Comparative Medicine. Her research will be supported by the vast physical resources and investigative expertise within the Dept. of Physiology and Cell Biology. Dr. Russell will be given maximum latitude for expressing her creativity and independence in the laboratory where she will spend 80% of her time. Her research will entail an extension of her own ideas and is based on results that she has obtained from preliminary studies. The guinea pig-Trichinella spiralis, host-parasite system will be used as a model to assess the influence of immediate hypersensitivity reactions (local anaphylaxis) in small intestinal mucosa on epithelial function. Sensitive electrophysiological and isotope tracer techniques in combination with immunological manipulations of the host will be used to study epithelial ion transport properties (Na+ and Cl- transport) and to identify cellular and subcellular pathways that integrate the immunological and other physiological systems. Results will contribute to the assessment of the underlying hypothesis that immunological elements, like neural and hormonal factors, regulate physiological functions in the gastrointestinal tract. Both the pathophysiological and immunophysiological implications of system interactions will be explored, ie. potential adverse and beneficial effects on the host. Twenty percent of Dr. Russell's time will involve nonresearch activities. She will attend faculty meetings; assist, nominally, in clinical and teaching duties; present seminars; present papers at scientific meetings; write scientific papers; visit selected laboratories in which related research is being performed. The entire program is designed to develop Dr. Russell as a scientist, academician and scholar.
The aim i s to provide resources, appropriate role models and a generally supportive environment to aid her in becoming an established, independent investigator who will be competitive for faculty positions at major universities within the United States.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Research Scientist Development Award - Research & Training (K01)
Project #
5K01RR000026-03
Application #
3069078
Study Section
Animal Resources Advisory Committee (AR)
Project Start
1984-07-01
Project End
1987-01-31
Budget Start
1986-07-01
Budget End
1987-01-31
Support Year
3
Fiscal Year
1986
Total Cost
Indirect Cost
Name
University of Texas Health Science Center Houston
Department
Type
Schools of Medicine
DUNS #
City
Houston
State
TX
Country
United States
Zip Code
77225
Harari, Y; Russell, D A; Castro, G A (1987) Anaphylaxis-mediated epithelial Cl- secretion and parasite rejection in rat intestine. J Immunol 138:1250-5
Russell, D A (1986) Mast cells in the regulation of intestinal electrolyte transport. Am J Physiol 251:G253-62
Russell, D A; Castro, G A (1985) Anaphylactic-like reaction of small intestinal epithelium in parasitized guinea-pigs. Immunology 54:573-9