This application for International Research Scientist Development Award is aimed to study the genetic susceptibility associated with Type 2 Diabetes (Type 2D) in an endogamous community from North India utilizing the opportunity to gain access to a unique population. Applicant's ultimate goal is to perform genome-wide scan on extended family pedigrees of diabetic sib-pairs to detect linkage of diabetes to putative genomic regions not previously identified. Once the linkage is found, to perform direct search for molecular variation in positional candidate genes, and to test for linkage and association using family-based methods. However due to the budgetary limitation of the present award, proposing a genome-wide scan is beyond the scope of this award. Therefore, the applicant is proposing pilot study to collect family material of 500 sib-pairs with following aims: 1) recruitment of 500 extended families with affected sib-pairs; 2) to perform dense mapping around some selected chromosomal regions, and 3) statistical analysis. With the help of this award, candidate will be able to build up resources and to initiate a large budgetary program to achieve the ultimate goal. The strategies used in US population studies suffer from the basic flaw of presence of heterogeneity in sample and require replication in genetically homogenous populations and India offers unique advantage due to the presence of small endogamous caste groups with intact families. It is an exciting and rare opportunity to study this population where diabetes have reached to epidemic scale and information on genetic epidemiological aspects hardly exists. Feasibility of conducting genetic research in India at the proposed site has already been established by the successful completion of previous Fogarty award and presently on-going Indo-US studies and testifies the adequacy and the environment to support this project. This training award will substantially contribute to the scientific development of the candidate to ultimately achieve an independent and productive international research career. It also fulfills Fogarty's mission to reduce health disparities between developed and developing countries. Identifying the susceptibility loci in a population with high diabetic/CHD risk may be important beyond Indians and will increase our understanding of the disease in other groups.

Agency
National Institute of Health (NIH)
Institute
Fogarty International Center (FIC)
Type
Research Scientist Development Award - Research & Training (K01)
Project #
3K01TW006087-02S1
Application #
6894217
Study Section
Special Emphasis Panel (ZAI1)
Program Officer
Jessup, Christine
Project Start
2002-09-18
Project End
2005-08-31
Budget Start
2003-09-01
Budget End
2004-08-31
Support Year
2
Fiscal Year
2004
Total Cost
$3,000
Indirect Cost
Name
University of Pittsburgh
Department
Genetics
Type
Schools of Public Health
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Imamura, Minako; Takahashi, Atsushi; Yamauchi, Toshimasa et al. (2016) Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes. Nat Commun 7:10531
Scott, William R; Zhang, Weihua; Loh, Marie et al. (2016) Investigation of Genetic Variation Underlying Central Obesity amongst South Asians. PLoS One 11:e0155478
Saxena, Richa; Bjonnes, Andrew; Prescott, Jennifer et al. (2014) Genome-wide association study identifies variants in casein kinase II (CSNK2A2) to be associated with leukocyte telomere length in a Punjabi Sikh diabetic cohort. Circ Cardiovasc Genet 7:287-95
Blackett, Piers R; Sanghera, Dharambir K (2013) Genetic determinants of cardiometabolic risk: a proposed model for phenotype association and interaction. J Clin Lipidol 7:65-81
Li, H; Kilpeläinen, T O; Liu, C et al. (2012) Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians. Diabetologia 55:981-95
Braun, Timothy R; Been, Latonya F; Singhal, Akhil et al. (2012) A replication study of GWAS-derived lipid genes in Asian Indians: the chromosomal region 11q23.3 harbors loci contributing to triglycerides. PLoS One 7:e37056
Schierer, Ashley; Been, Latonya F; Ralhan, Sarju et al. (2012) Genetic variation in cholesterol ester transfer protein, serum CETP activity, and coronary artery disease risk in Asian Indian diabetic cohort. Pharmacogenet Genomics 22:95-104
Been, L F; Hatfield, J L; Shankar, A et al. (2012) A low frequency variant within the GWAS locus of MTNR1B affects fasting glucose concentrations: genetic risk is modulated by obesity. Nutr Metab Cardiovasc Dis 22:944-51
Rees, S D; Islam, M; Hydrie, M Z I et al. (2011) An FTO variant is associated with Type 2 diabetes in South Asian populations after accounting for body mass index and waist circumference. Diabet Med 28:673-80
Been, Latonya F; Ralhan, Sarju; Wander, Gurpreet S et al. (2011) Variants in KCNQ1 increase type II diabetes susceptibility in South Asians: a study of 3,310 subjects from India and the US. BMC Med Genet 12:18

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