Abstract

This application is a renewal of my K02 award, which had the stated goal of developing an interdisciplinary program of research aimed at advancing our understanding of how genetic influences impact the development of alcohol use disorders by integrating findings across twin studies, gene identification projects, and longitudinal, community-based samples. Over the past four years of the project, with the protected research time afforded by my K award, I have published >70 peer-reviewed papers and obtained three new R01s, while continuing my role as PI/site PI on four additional existing grants. In the renewal of my K02, I propose to expand my program of research to incorporate prevention/intervention studies in order to actualize on the

Public Health Relevance

The complexity of the genetics of alcohol dependence necessitates an interdisciplinary perspective; too often research in different areas is conducted in isolation. By integrating twin studies, gene identification projects, community-based samples, and prevention/intervention projects, we can characterize developmental pathways of risk by which genetic and environmental influences contribute to alcohol use disorders, and importantly, use that information to develop more effective, tailored programs of prevention and intervention.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Scientist Development Award - Research (K02)
Project #
5K02AA018755-07
Application #
9128531
Study Section
Neuroscience Review Subcommittee (AA)
Program Officer
Parsian, Abbas
Project Start
2010-02-01
Project End
2020-08-31
Budget Start
2016-09-01
Budget End
2017-08-31
Support Year
7
Fiscal Year
2016
Total Cost
Indirect Cost

  Institution

Name
Virginia Commonwealth University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
105300446
City
Richmond
State
VA
Country
United States
Zip Code
23298

  Publications

Edwards, Alexis C; Deak, Joseph D; Gizer, Ian R et al. (2018) Meta-Analysis of Genetic Influences on Initial Alcohol Sensitivity. Alcohol Clin Exp Res 42:2349-2359
Thomas, Nathaniel S; Adkins, Amy; Aliev, Fazil et al. (2018) Alcohol Metabolizing Polygenic Risk for Alcohol Consumption in European American College Students. J Stud Alcohol Drugs 79:627-634
Korhonen, Tellervo; Sihvola, Elina; Latvala, Antti et al. (2018) Early-onset tobacco use and suicide-related behavior - A prospective study from adolescence to young adulthood. Addict Behav 79:32-38
Hawn, Sage E; Lind, Mackenzie J; Conley, Abigail et al. (2018) Effects of social support on the association between precollege sexual assault and college-onset victimization. J Am Coll Health 66:467-475
Dick, Danielle M (2018) Mapping Risk from Genes to Behavior: The Enduring and Evolving Influence of Irving Gottesman's Endophenotype Concept. Twin Res Hum Genet 21:306-309
Hawn, Sage E; Sheerin, Christina M; Webb, Bradley T et al. (2018) Replication of the Interaction of PRKG1 and Trauma Exposure on Alcohol Misuse in an Independent African American Sample. J Trauma Stress 31:927-932
Dick, Danielle M; Barr, Peter B; Cho, Seung Bin et al. (2018) Post-GWAS in Psychiatric Genetics: A Developmental Perspective on the ""Other"" Next Steps. Genes Brain Behav 17:e12447
Salvatore, Jessica E; Savage, Jeanne E; Barr, Peter et al. (2018) Incorporating Functional Genomic Information to Enhance Polygenic Signal and Identify Variants Involved in Gene-by-Environment Interaction for Young Adult Alcohol Problems. Alcohol Clin Exp Res 42:413-423
Savage, Jeanne E; Rose, Richard J; Pulkkinen, Lea et al. (2018) Early maturation and substance use across adolescence and young adulthood: A longitudinal study of Finnish twins. Dev Psychopathol 30:79-92
Tubbs, Justin D; Savage, Jeanne E; Adkins, Amy E et al. (2018) Mindfulness moderates the relation between trauma and anxiety symptoms in college students. J Am Coll Health :1-11

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