Age trajectories of total and cause-specific mortality, morbidity, and disability as well as those of biomarkers are fundamental data in aging research. Patterns and differentials of these age trajectories reflect the mechanisms of senescence, evolutionary backgrounds of the mechanisms, relationships between senescence and diseases, and environmental and genetic effects on senescence. In order to analyze the age trajectories in more depth than in previous studies and detect clues about the underlying senescent processes, innovative quantitative approaches need to be developed. Thus statistical demographers experienced in age variation analysis have high potentials to make important contributions to biomedical gerontology. The background of the candidate, Shiro Horiuchi, is formal and mathematical demography. This proposal seeks funds for him to develop his career as an independent scientist in the biodemography of aging, by conducting the proposed research, strengthening this biomedical background, and broadening his collaborative network with biomedical investigators. His environment is highly suitable for his career development: the Rockefeller University is known for high quality in biomedical research and cooperates closely in training and research with Cornell University Medical College and Memorial Sloan Kettering Institute; and the Laboratory of Populations at RU pursues quantitative approaches to biomedical problems. (Since his research is statistical data analysis, other sources of research support will not necessarily be needed.) Horiuchi's recent studies have underscored the importance of age variations in the rate of senescence progression. In the proposed research, he will (a) compare patterns of the rate of relative mortality increase with age (life table aging rate, or LAR) among various species; (b) examine if environmental and genetic risk factors (in particular, smoking and high-fat diet) not only raise the overall levels of total and cause-specific mortality but also accelerate their age-related increases; (c) investigate senescence-rooted interdependence among major causes of death by examining interrelationships among LAR patterns of degenerative diseases; (d) analyze aging rate patterns of morbidity, disability, and biomarkers with emphasis on dementia-related variables; and compare differential aging rate profiles by race/sex categories.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Scientist Development Award - Research (K02)
Project #
5K02AG000778-04
Application #
6371934
Study Section
National Institute on Aging Initial Review Group (NIA)
Program Officer
Shrestha, Laura B
Project Start
1998-07-01
Project End
2003-06-30
Budget Start
2001-07-15
Budget End
2002-06-30
Support Year
4
Fiscal Year
2001
Total Cost
$106,205
Indirect Cost
Name
Rockefeller University
Department
Miscellaneous
Type
Other Domestic Higher Education
DUNS #
071037113
City
New York
State
NY
Country
United States
Zip Code
10065
Horiuchi, Shiro; Finch, Caleb E; Mesle, France et al. (2003) Differential patterns of age-related mortality increase in middle age and old age. J Gerontol A Biol Sci Med Sci 58:495-507
Wilmoth, J R; Deegan, L J; Lundstrom, H et al. (2000) Increase of maximum life-span in Sweden, 1861-1999. Science 289:2366-8
Wilmoth, J R; Horiuchi, S (1999) Rectangularization revisited: variability of age at death within human populations. Demography 36:475-95