Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Scientist Development Award - Research (K02)
Project #
1K02AI001461-01
Application #
2057716
Study Section
Allergy & Clinical Immunology-1 (AITC)
Project Start
1996-09-01
Project End
2001-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Rhode Island Hospital (Providence, RI)
Department
Type
DUNS #
161202122
City
Providence
State
RI
Country
United States
Zip Code
02903
Fowler, Dale E; Yang, Shaolong; Zhou, Mian et al. (2003) Adrenomedullin and adrenomedullin binding protein-1: their role in the septic response. J Surg Res 109:175-81
Yang, Shaolong; Zhou, Mian; Chaudry, Irshad H et al. (2002) Novel approach to prevent the transition from the hyperdynamic phase to the hypodynamic phase of sepsis: role of adrenomedullin and adrenomedullin binding protein-1. Ann Surg 236:625-33
Ornan, David A; Chaudry, Irshad H; Wang, Ping (2002) Saturation of adrenomedullin receptors plays an important role in reducing pulmonary clearance of adrenomedullin during the late stage of sepsis. Biochim Biophys Acta 1586:299-306
Yang, Shaolong; Lim, Yow-Pin; Zhou, Mian et al. (2002) Administration of human inter-alpha-inhibitors maintains hemodynamic stability and improves survival during sepsis. Crit Care Med 30:617-22
Kuebler, Joachim F; Jarrar, Doraid; Toth, Balazs et al. (2002) Estradiol administration improves splanchnic perfusion following trauma-hemorrhage and sepsis. Arch Surg 137:74-9
McKindley, David S; Boulet, Judah; Sachdeva, Karuna et al. (2002) Endotoxic shock alters the pharmacokinetics of lidocaine and monoethylglycinexylidide. Shock 17:199-204
Ba, Zheng F; Wang, Ping; Kuebler, Joachim F et al. (2002) Flutamide induces relaxation in large and small blood vessels. Arch Surg 137:1180-6
Zhou, Mian; Ba, Zheng F; Chaudry, Irshad H et al. (2002) Adrenomedullin binding protein-1 modulates vascular responsiveness to adrenomedullin in late sepsis. Am J Physiol Regul Integr Comp Physiol 283:R553-60
Yang, Shaolong; Chung, Chun-Shiang; Ayala, Alfred et al. (2002) Differential alterations in cardiovascular responses during the progression of polymicrobial sepsis in the mouse. Shock 17:55-60
Yang, Shaolong; Zhou, Mian; Fowler, Dale E et al. (2002) Mechanisms of the beneficial effect of adrenomedullin and adrenomedullin-binding protein-1 in sepsis: down-regulation of proinflammatory cytokines. Crit Care Med 30:2729-35

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