This application is to renew a Research Scientist Development Award, Level 2 (K02) from NIDA. The goal of this RSDA is to free the applicant from clinical and administrative duties so he can conduct and acquire training in laboratory, treatment and epidemiological studies on nicotine and caffeine. Despite increasing public and governmental concerns around nicotine and caffeine use and dependence, to our knowledge, this is the only NIDA-funded RSDA that focuses on nicotine or caffeine. In the first 4 yrs of the prior KO2, the applicant published 108 articles, including articles in NEJM, JAMA and JPET, fostered growth of the University of Vermont, Human Behavioral Pharmacology Laboratory (HBPL), mentored several undergraduate graduate, post- graduate and medical students and several physicians served as a resource to the University of Vermont, the State of VT, NIDA and other federal agencies, the general public and the media on drug abuse matters, especially policy issues about nicotine and caffeine use. In the renewal the applicant proposes laboratory studies to test the conditions that control the reinforcing and subjective effects of nicotine and caffeine, nicotine and caffeine withdrawal, and the effect of nicotine and caffeine on the use of other drugs of abuse; treatment studies to test new nicotine and nonnicotine therapies for nicotine dependence both in the general population and in alcohol/drug abusers; and epidemiological studies to examine the utility of DSM/WHO generic criteria for drug dependence/abuse when applied to nicotine and caffeine. In addition, the applicant will continue collaboration with Drs. Bickel and Higgins in studies of alcohol, benzodiazepine, cocaine and opioid use/dependence.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Scientist Development Award - Research (K02)
Project #
5K02DA000109-15
Application #
2897566
Study Section
Special Emphasis Panel (SRCD (52))
Project Start
1985-09-30
Project End
2000-08-31
Budget Start
1999-09-01
Budget End
2000-08-31
Support Year
15
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Vermont & St Agric College
Department
Psychiatry
Type
Schools of Medicine
DUNS #
066811191
City
Burlington
State
VT
Country
United States
Zip Code
05405
Kamien, J B; Bickel, W K; Smith, B J et al. (1997) Secobarbital in humans discriminating triazolam under two-response and novel-response procedures. Pharmacol Biochem Behav 58:983-91
Hughes, J R (1996) The future of smoking cessation therapy in the United States. Addiction 91:1797-802
Fagerstrom, K O; Kunze, M; Schoberberger, R et al. (1996) Nicotine dependence versus smoking prevalence: comparisons among countries and categories of smokers. Tob Control 5:52-6
Hughes, J R; Higgins, S T; Bickel, W K (1994) Common errors in the pharmacologic treatment of drug dependence and withdrawal. Compr Ther 20:89-94
Hughes, J R (1993) Pharmacotherapy for smoking cessation: unvalidated assumptions, anomalies, and suggestions for future research. J Consult Clin Psychol 61:751-60