The overall aim of this proposal is to support the continuing development of the applicant as a scientist in the field of drug abuse treatment. The applicant's program of research is driven by two main themes: 1) That pharmacotherapies may be developed by considering the heterogeneity of drug addicted samples, and by targeting interventions to specific subgroups; and 2) That the Medications Development effort for cocaine abuse is in need of improved methods for early Phase II trials in which preliminary indications of efficacy are sought. During the proposed K02, the applicant will direct three main projects 1) A placebo-controlled trial of sertraline in methadone patients with depressive disorders and illicit drug use (R01 DA08950); 2) A placebo-controlled trial of desipramine for cocaine abusers with depressive disorders (P50 DA09236, Project 3); and 3) A series of early Phase II pilot trials for cocaine abuse candidate medications, employing a new placebo-controlled, multiple- baselines design, and incorporating human laboratory measures (R01 DA09582). The applicant will consult on epidemiologic and treatment studies of colleagues and will mentor junior collaborators on related treatment studies. The applicant will continue to pursue a training plan focused on methodology and statistics of clinical trials. Finally, the applicant will contribute to a variety of educational activities at the Medical Center, and will assume a leadership role in mentoring young clinical investigators and in the development of clinical research within the Division on Substance Abuse.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Scientist Development Award - Research (K02)
Project #
5K02DA000288-02
Application #
2390970
Study Section
Special Emphasis Panel (SRCD (52))
Project Start
1996-04-01
Project End
2001-03-31
Budget Start
1997-04-01
Budget End
1998-03-31
Support Year
2
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Columbia University (N.Y.)
Department
Psychiatry
Type
Schools of Medicine
DUNS #
167204994
City
New York
State
NY
Country
United States
Zip Code
10032
Brooks, Adam C; Comer, Sandra D; Sullivan, Maria A et al. (2010) Long-acting injectable versus oral naltrexone maintenance therapy with psychosocial intervention for heroin dependence: a quasi-experiment. J Clin Psychiatry 71:1371-8
Raby, Wilfrid Noel; Carpenter, Kenneth M; Rothenberg, Jami et al. (2009) Intermittent marijuana use is associated with improved retention in naltrexone treatment for opiate-dependence. Am J Addict 18:301-8
Aharonovich, Efrat; Amrhein, Paul C; Bisaga, Adam et al. (2008) Cognition, commitment language, and behavioral change among cocaine-dependent patients. Psychol Addict Behav 22:557-62
Blanco, Carlos; Olfson, Mark; Goodwin, Renee D et al. (2008) Generalizability of clinical trial results for major depression to community samples: results from the National Epidemiologic Survey on Alcohol and Related Conditions. J Clin Psychiatry 69:1276-80
Levin, Frances R; Bisaga, Adam; Raby, Wilfrid et al. (2008) Effects of major depressive disorder and attention-deficit/hyperactivity disorder on the outcome of treatment for cocaine dependence. J Subst Abuse Treat 34:80-9
Carpenter, Kenneth M; Smith, Jennifer L; Aharonovich, Efrat et al. (2008) Developing therapies for depression in drug dependence: results of a stage 1 therapy study. Am J Drug Alcohol Abuse 34:642-52
Rubin, Eric; Aharonovich, Efrat; Bisaga, Adam et al. (2007) Early abstinence in cocaine dependence: influence of comorbid major depression. Am J Addict 16:283-90
Collins, Eric D; Horton, Terry; Reinke, Katherine et al. (2007) Using buprenorphine to facilitate entry into residential therapeutic community rehabilitation. J Subst Abuse Treat 32:167-75
Aharonovich, Efrat; Garawi, Fatima; Bisaga, Adam et al. (2006) Concurrent cannabis use during treatment for comorbid ADHD and cocaine dependence: effects on outcome. Am J Drug Alcohol Abuse 32:629-35
Bisaga, Adam; Aharonovich, Efrat; Garawi, Fatima et al. (2006) A randomized placebo-controlled trial of gabapentin for cocaine dependence. Drug Alcohol Depend 81:267-74

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