This is a competitive renewal application for a K02 Independent Scientist Award (ISA) from NIDA. The applicant is Eric Strain, a physician-researcher in the Department of Psychiatry at Johns Hopkins University School of Medicine. Dr. Strain has devoted his career to research on drug abuse and to treatment of substance abusing patients, with his primary interest focused upon the development of opioid and cocaine dependence treatment medications. This work has included residential human laboratory studies as well as outpatient clinical trials. There are six short-term and three long-term career goals addressed through the support provided by this ISA. Short-term career goals are: 1) to determine efficacy, safety, and clinical pharmacology of novel substance abuse treatment medications under inpatient experimental conditions, 2) to study efficacy and safety of medications for the treatment of substance abuse disorders utilizing, outpatient clinical trials, 3) to develop and apply methodologies integrating pharmacotherapies with behavioral therapies in clinical trials of substance abuse treatments, 4) to examine the influence of individual characteristics in the course and outcome of substance abuse treatment, 5) to refine expertise in the development process of new medications for the treatment of substance abuse disorders, and 6) to disseminate research findings. Achieving these short-term goals will contribute to accomplishing the first two long-term goals: to contribute new knowledge about the treatment of substance abuse disorder, and to build recognition as an expert in drug abuse treatment and research issues. The final long-term goal is to serve as a mentor and role model for young physicians interested in pursuing a career in substance abuse research. This application's Research Plan provides illustrative investigations that furnish a mechanism for achieving the career goals. These studies examine the pharmacological effects of opioids in human laboratory studies, and test a pharmacotherapy combined with a behavioral therapy in an outpatient clinical trial treating cocaine dependence. This research will be conducted through the Behavioral Pharmacology Research Unit (BPRU), a component of the Hopkins Department of Psychiatry. Dr. Strain has the strong support of the BPRU, the Department of Psychiatry, and the Hopkins School of Medicine, and this ISA provides a mechanism for ensuring the continuation of his highly productive career in substance abuse research. Thus, this ISA represents a good investment by NIDA.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Scientist Development Award - Research (K02)
Project #
5K02DA000332-08
Application #
6721240
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Oversby, Steven
Project Start
1997-04-01
Project End
2007-03-31
Budget Start
2004-04-01
Budget End
2005-03-31
Support Year
8
Fiscal Year
2004
Total Cost
$125,388
Indirect Cost
Name
Johns Hopkins University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Duke, Angela N; Correia, Christopher J; Walsh, Sharon L et al. (2010) Acute effects of intramuscular and sublingual buprenorphine and buprenorphine/naloxone in non-dependent opioid abusers. Psychopharmacology (Berl) 211:303-12
Chisolm, Margaret S; Tuten, Michelle; Strain, Eric C et al. (2009) Screening for Mood Disorder in Pregnant Substance-dependent Patients. Addict Disord Their Treat 8:88-98
Walsh, S L; Chausmer, A E; Strain, E C et al. (2008) Evaluation of the mu and kappa opioid actions of butorphanol in humans through differential naltrexone blockade. Psychopharmacology (Berl) 196:143-55
Lofwall, Michelle R; Schuster, Alyson; Strain, Eric C (2008) Changing profile of abused substances by older persons entering treatment. J Nerv Ment Dis 196:898-905
Wedam, Erich F; Bigelow, George E; Johnson, Rolley E et al. (2007) QT-interval effects of methadone, levomethadyl, and buprenorphine in a randomized trial. Arch Intern Med 167:2469-75
Lofwall, Michelle R; Walsh, Sharon L; Bigelow, George E et al. (2007) Modest opioid withdrawal suppression efficacy of oral tramadol in humans. Psychopharmacology (Berl) 194:381-93
Lofwall, Michelle R; Walsh, Sharon L; Bigelow, George E et al. (2007) Experimentally-induced spontaneous opiate withdrawal: relationship to cigarette craving and expired air carbon monoxide. Am J Addict 16:310-5
Carroll, C Patrick; Kidorf, Michael; Strain, Eric C et al. (2007) Comparison of demographic and clinical characteristics between opioid-dependent individuals admitted to a community-based treatment setting and those enrolled in a research-based treatment setting. J Subst Abuse Treat 33:355-61
Rosado, James; Walsh, Sharon L; Bigelow, George E et al. (2007) Sublingual buprenorphine/naloxone precipitated withdrawal in subjects maintained on 100mg of daily methadone. Drug Alcohol Depend 90:261-9
Correia, Christopher J; Walsh, Sharon L; Bigelow, George E et al. (2006) Effects associated with double-blind omission of buprenorphine/naloxone over a 98-h period. Psychopharmacology (Berl) 189:297-306

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